The Effect of Hemodialysis of on Serum Troponin I level in Patients with Renal Disease and Normal Left Ventricular Ejection Fraction

Authors

1 1- Professor, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 2- Resident, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 3- Assistant Professor, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: One of the important criteria for acute myocardial ischemia is the level of troponin. The fact that
troponin is excreted by the kidneys, and patients under dialysis may have a high level of it, makes the diagnosis
of acute ischemia difficult. The present study aimed to evaluate the effect of hemodialysis on serum troponin I
level in patients with end-stage renal disease (ESRD) and normal left ventricular ejection fraction (LVEF).
Methods: In this cross-sectional study, 106 patients with ESRD and LVEF of more than 50% who underwent
hemodialysis during 2018-2019 in Khorshid and Alzahra hospitals in Isfahan, Iran, were studied. The serum
levels of troponin I were measured and compared before and after hemodialysis.
-Findings: The mean serum level of troponin I was 0.031 ± 0.068 and 0.028 ± 0.036 ng/dl before and after
hemodialysis, respectively, with no statistically difference (P = 0.590). The mean difference of troponin level
before and after the hemodialysis was 0.003 ± 0.06 ng/ml. Moreover, the changes of troponin levels were not
significantly associated with age, sex, duration of dialysis, hemoglobin and hematocrit levels, LVEF, cause of
renal failure, and type of underlying disease.
Conclusion: The findings of the present study showed that hemodialysis did not have a significant effect on
changes in troponin I levels, and the level of troponin I did not appear to be a suitable biomarker for the
expression of cardiovascular disease in hemodialysis patients with normal LVEF.

Keywords

References

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Journal of Isfahan Medical School
Volume 39, Issue 655
November and December 2022
Pages 993-998

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History

  • Receive Date: 03 April 2022
  • Accept Date: 03 April 2022

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