The Preventive Effects of Aminophylline, Metoclopramide, and Acetaminophen on Postoperative Pain after Strabismus Surgery; A Randomized Clinical Trial Study

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Anesthesiology, School of Medicine AND Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Professor, Department of Anesthesiology, School of Medicine AND Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: There are many drugs to control the pain after surgeries. Aminophylline, metoclopramide, and acetaminophen are known to be able to control pain. In this study, we aimed to compare the effects of these three drugs in controlling pain after strabismus correction surgery.Methods: This was a double-blinded randomized clinical trial on 120 patients underwent strabismus correction surgery in Feiz hospital, Isfahan, Iran. Patients were randomized into 4 groups of aminophylline, metoclopramide, acetaminophen, and placebo. All patients and surgeons were unaware of groups and drugs. After strabismus surgery, patients were assessed using visual analogue scale (VAS) to evaluate their pain. Hemodynamic parameters, as well as extubation and recovery times after surgeries were also evaluated.Findings: Postoperative pain assessments indicated a lower pain intensity in acetaminophen, metoclopramide, and aminophylline, respectively, compared to placebo at the time of recovery entrance and 15 and 30 minutes afterwards (P < 0.001).Conclusion: According to the results of present study, acetaminophen has a better effect in controlling postoperative pain than metoclopramide and aminophylline.

Keywords

References

  1. van Rijn LJ, van De Ven SJ, Krijnen JS, Jansen SM, Bakels AJ, Langenhorst AM. Tendon elongation with bovine pericardium (Tutopatch(R)) when conventional strabismus surgery is not possible. Eur J Ophthalmol 2016; 26(3): 193-202.
  2. Chou R, Gordon DB, de Leon-Casasola OA, Rosenberg JM, Bickler S, Brennan T, et al. Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain 2016; 17(2): 131-57.
  3. Bendixen M, Jorgensen OD, Kronborg C, Andersen C, Licht PB. Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer: A randomised controlled trial. Lancet Oncol 2016; 17(6): 836-44.
  4. Sadrossadat H, Ahangari A, Marashi S, Yaghooti AA. Delirium and pain after strabismus surgery in children undergo general anesthesia: a comparison of paracetamol and meperidine. Arch Anesth Crit Care; 3(2): 308-12.
  5. Salimi A, Mottaghi K, Sabetkasaei M, Mohajerani SA, Bokai AN, Moini Zanjani T. Abstract PR328: Carbamazepine augments morphine analgesia on postoperative pain in opioid-dependent patients. Anesth Analg 2016; 123(3S): 423.
  6. Suneby Jagers JV, Ji M, Rothwell B, Easton PA. Aminophylline increases parasternal muscle action in awake canines. Pulm Pharmacol Ther 2019; 56: 1-7.
  7. Wu C, Guan D, Ren M, Ma Z, Wan C, Cui Y, et al. Aminophylline for treatment of postdural puncture headache: A randomized clinical trial. Neurology 2018; 90(17): e1523-e1529.
  8. Kenyon M, Phillips B, DeWit C. Personal observation: Intravenous aminophylline treatment for migraine. Can J Ge. Intern Med 2012; 7(4): 129-34.
  9. Berger J, Lester P, Rodrigues L. Medical therapy of malignant bowel obstruction with octreotide, dexamethasone, and metoclopramide. Am J Hosp Palliat Care 2016; 33(4): 407-10.
  10. Factor SA. Metoclopramide therapy for migraine: Worth the risk? Neurology 2014 [Online]. [cited]; Available from: URL:https://n.neurology.org/content/metoclopramide-therapy-migraine-worth-risk
  11. Amiri H, Ghodrati N, Nikuyeh M, Shams-Vahdati S, Jalilzadeh-Binazar M. Comparison of granisetron and metoclopramide in the treatment of pain and emesis in migraine patients: A randomized controlled trial study. Turk J Emerg Med 2017; 17(2): 61-4.
  12. Mallet C, Eschalier A, Daulhac L. Paracetamol: Update on its Analgesic Mechanism of Action. IntechOpen 2017 [Online]. [cited 2017 May 4]; Available from: URL:https://www.intechopen.com/books/pain-relief-from-analgesics-to-alternative-therapies/paracetamol-update-on-its-analgesic-mechanism-of-action
  13. Carlsson AM. Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Pain 1983; 16(1): 87-101.
  14. De Oliveira GSJ, Castro-Alves LJ, McCarthy RJ. Single-dose systemic acetaminophen to prevent postoperative pain: A meta-analysis of randomized controlled trials. Clin J Pain 2015; 31(1): 86-93.
  15. McNicol ED, Ferguson MC, Haroutounian S, Carr DB, Schumann R. Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain. Cochrane Database Syst Rev 2016; (5): CD007126.
  16. Dahl JB, Nielsen RV, Wetterslev J, Nikolajsen L, Hamunen K, Kontinen VK, et al. Post-operative analgesic effects of paracetamol, NSAIDs, glucocorticoids, gabapentinoids and their combinations: A topical review. Acta Anaesthesiol Scand 2014; 58(10): 1165-81.
  17. Heidari-Tabaee-Zavareh S M, Saryazdi H, Salehi J. Comparing the effect of Metoclopramide and Ketamine as a preemptive analgesia on postoperative pain. J Shahrekord Univ Med Sci 2011; 13(2): 38-45. [In Persian].
  18. Hajigholam Saryazdi H, Shabanian S, Jabalameli M, Khorram Ghahfarrokhi B. The effect of adding metoclopramide to subcutaneous lidocaine on postoperative pain after lower abdominal surgery with general anesthesia. J Isfahan Med Sch 2011; 28(123): 1917-28. [In Persian].
  19. Wu C, Lian Y, Guan D, Wang L, Miao Y, Xie N, et al. A multicenter clinical study on treating post-dural puncture headache with an intravenous injection of aminophylline. Pain Physician 2016; 19(5): E761-E765.
  20. Wu C, Lian Y, Xie N. Aminophylline injection alleviates pain in postdural puncture headache. Pain Med 2015; 16(10): 2038-40.
  21. Moradi-Farsani D, Akrami F, Naghibi K, Alikiaii B, Nazemorroaya B. The effect of age and sex on postoperative pain after deep vitrectomy. J Isfahan Med Sch 2017; 34(415): 1660-5.
  22. Moradi-Farsani D, Naghibi K, Taheri S, Ali-Kiaii B, Rahimi-Varposhti M. Effects of age and gender on acute postoperative pain after cataract surgery under topical anesthesia and sedation. J Isfahan Med Sch 2017; 34(414): 1627-33.
  23. Rahimi-Varposhti M, Moradi-Farsani D, Salehnia A, Montazeri K, Shafa A. Effects of magnesium sulfate on pain, nausea/vomiting, and anesthetic consumption after corneal transplantation and vitrectomy. J Isfahan Med Sch 2017; 35(423): 278-84.
  24. Moradi-Farsani D, Hatami-Maskooni MR, Nazemolroaya B. Comparing the Effects of Fentanyl and Sufentanil on Hemodynamic Parameters and Acute Pain Intensity after Deep Vitrectomy Surgery. J Isfahan Med Sch 2018; 36(477): 419-25.
  25. Naghibi K, Dodangeh M, Hashemi ST, Moradi-Farsani D. Evaluation and Comparison of the Effects of Propofol, Dexamethasone, and Ondonestrone in the Prevention of Complications during and after Cataract Surgery. J Isfahan Med Sch 2018; 36(475): 372-8.
  26. Rahimi M, Montazeri K, Kamali L, Moradi M, Naghibi Kh. Comparing the Effects of Magnesium Sulfate and Nitroglycerin on the Control of Hypertension during and after Cataract Surgery under Local Anesthesia and Intravenous Sedation. J Isfahan Med Sch 2016; 33(361): 2076-83.
Journal of Isfahan Medical School
Volume 37, Issue 548 - Serial Number 548
September and October 2020
Pages 1185-1191

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History

  • Receive Date: 01 September 2019
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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