The Effects of Aloe Vera against Gentamicin-Induced Tubular Toxicity

Document Type : مقاله کوتاه

Authors

1 School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

2 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

3 Professor, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

Abstract

Background: Aloe vera is a well-known plant, has been used as alternative medicine. This study aimed to determine the antioxidant activity and phenolic and flavonoid quantities of Aloe vera to investigate the nephroprotective and curative effects of aqueous extract of this plant on gentamicin-induced tubular toxicity in male Wistar rats.Methods: This preclinical study was performed on 60 male Wistar rats randomly divided into 6 groups of 10. Group I were treated with vehicle (distilled water) as control. Group II received 300 mg/kg/day Aloe vera for three days next orally, then, the same oral Aloe vera plus 80 mg/kg/day intravenous gentamicin for seven more days. Group III received the same amount of oral Aloe vera for 10 days. Group IV received the same amount of intravenous gentamicin for 7 days. Group V received the same amount of intravenous gentamicin for 7 days and then, saline for ten days. Group VI received the same amount of intravenous gentamicin for 7 days and then, the same amount of oral Aloe vera for 10 days.Findings: The amounts of flavonoid and phenolic component in Aloe vera extract were 43.0 ± 3.8 mg/g of rutin equivalent and 80.1 ± 3.8 mg/g of gallic acid equivalent, respectively. The antioxidant activity of the extract was 38%. The intensity of nephrotoxicity in group 2, which received 300 mg/kg/day Aloe vera orally as prophylaxis was not significantly different from the group I and from the group II, which received the same amount of Aloe vera without gentamicin. In 4, 5, 6 groups the intensity of nephrotoxicity was more than 1, 2 and 3 groups.Conclusion: This finding reveals that despite the antioxidants and polyphenol compounds of Aloe vera, it cannot prevent or treat the gentamicin-induced nephrotoxicity.

Keywords

References

  1. Tavafi M. Inhibition of gentamicin-induced renal tubular cell necrosis. J Nephropathol 2012; 1(2): 83-6.
  2. Tamadon MR, Ardalan MR, Nasri H. World Kidney Day 2013; acute renal injury; a global health warning. J Parathyr Dis 2013; 1(2): 27-8.
  3. Baradaran A. Ameliorative properties of herbal drugs on diabetic kidney disease. Acta Epidemioendocrinol 2016; 1(1): e01.
  4. Nasri H. Herbal drugs and new concepts on its use. J Prev Epidemiol 2016; 1:e01.
  5. Kafeshani M. Ginger, micro-inflammation and kidney disease. J Renal Endocrinol 2015; 1: e04.
  6. Spasovski D. Renal markers for assessment of renal tubular and glomerular dysfunction. J Nephropharmacol 2013; 2: 23-5.
  7. Gheissari A. Acute kidney injury and renal angina. J Renal Inj Prev 2013; 2(2): 33-4.
  8. Gupta A, Chaphalkar S. Immunopharmacological screening of aqueous root extract of Santalum album. J HerbMed Pharmacol 2016; 5(1): 7-11.
  9. Kafeshani M. Diet and immune system. Immunopathol Persa. 2015; 1(1): e04.
  10. Mirazi N, Rezaei M, Mirhoseini M. Hypoglycemic effect of Satureja montanum L. hydroethanolic extract on diabetic rats. J HerbMed Pharmacol 2016; 5(1): 17-22.
  11. Baradaran A. Vascular protective effects of herbal antioxidants. Angiol Persica Acta 2016; 1(1): e01.
  12. Sarrafchi A, Bahmani M, Shirzad H, Rafieian-Kopaei M. Oxidative stress and Parkinson's disease: New hopes in treatment with herbal antioxidants. Curr Pharm Des 2016; 22(2): 238–246.
  13. Rafieian-Kopaei M, Baradaran A, Rafieian M. Plants antioxidants: From laboratory to clinic. J Nephropathol 2013; 2(2): 152-3.
  14. Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S. Beneficial effects of aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin Exp Pharmacol Physiol 2006; 33(3): 232-7.
  15. Nasri H, Rafieian-Kopaei M . Herbal medicine and diabetic kidney disease. J Nephropharmacol 2013; 2(1):1-2.
  16. Hutter JA, Salman M, Stavinoha WB, Satsangi N, Williams RF, Streeper RT, et al. Antiinflammatory C-glucosyl chromone from Aloe barbadensis. J Nat Prod 1996; 59(5): 541-3.
  17. Chithra P, Sajithlal GB, Chandrakasan G. Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Mol Cell Biochem 1998; 181(1-2): 71-6.
  18. Hu Y, Xu J, Hu Q. Evaluation of antioxidant potential of aloe vera (Aloe barbadensis miller) extracts. J Agric Food Chem 2003; 51(26): 7788-91.
  19. Saki K, Hassanzad-Azar H, Naghdi N, Bahmani M. Ginkgo biloba; an effective medicinal plant on neurological disorders. J Prev Epidemiol 2016; 1: e03.
  20. Ardalan MR, Rafieian-Kopaei M. Is the safety of herbal medicines for kidneys under question? J Nephropharmacol 2013; 2(2): 11-2.
  21. Ardalan MR, Sanadgol H, Nasri H, Baradaran A, Tamadon MR, Rafieian-Kopaei R. Impact of vitamin D on the immune system in kidney disease. J Parathyr Dis 2013; 1(2): 17-20.
  22. Nasri H. Cisplatin and renal injury; current concepts. J Renal Inj Prev 2013; 2(3): 89-90.
  23. Rafieian-Kopaei M, Baradaran A. On the occasion of world diabetes day 2105; act today to change tomorrow. J Renal Endocrinol 2015; 1: e02.
  24. Nasri H, Abedi-Gheshlaghi Z, Rafieian-Kopaei M. Curcumin and kidney protection; current findings and new concepts. Acta Persica Pathophysiol. 2016; 1(1): e01.
  25. Ro JY, Lee BC, Kim JY, Chung YJ, Chung MH, Lee SK, et al. Inhibitory mechanism of aloe single component (alprogen) on mediator release in guinea pig lung mast cells activated with specific antigen-antibody reactions. J Pharmacol Exp Ther 2000; 292(1): 114-21.
  26. Paulsen E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol 2005; 19(3): 326-31.
  27. Khodadadi S. Role of herbal medicine in boosting immune system. Immunopathol Persa. 2015; 1(1): e01.
Journal of Isfahan Medical School
Volume 33, Issue 365 - Serial Number 365
November and December 2016
Pages 2316-2320

Files

History

  • Receive Date: 22 August 2015
  • Revise Date: 02 November 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics