Comparison of Blood Concentration of Molybdenum in Patients with Metabolic Syndrome and with or without Type 2 Diabetes

Document Type : Original Article (s)

Authors

1 Department of Clinical Biochemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associate Professor, Department of Clinical Biochemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

3 Department of Biochemistry, Payame Noor University of Isfahan, Isfahan, Iran

Abstract

Background: Several studies reported that there is a relationship between type 2 diabetes or metabolic syndrome and alteration in trace elements homeostasis. This study was designed to evaluate the whole blood concentration of molybdenum in patients with metabolic syndrome and with or without type 2diabetes.Methods: This cross-sectional study involved 125 subjects (men and women) divided in three groups based on criteria defined for type 2 diabetes and metabolic syndrome. The subjects were normal control (n = 40), metabolic syndrome without type 2 diabetes (n = 45), and metabolic syndrome with type 2 diabetes (n = 40). In all the subjects, whole blood level of molybdenum was measured using graphite furnace atomic absorption spectroscopy (GFAAS) after acid digestion by HNO3 (1N) and H2O2 (30%). The data were analyzed using SPSS software.Findings: Whole blood concentration of molybdenum in patients with metabolic syndrome without type 2 diabetes (4.72 ± 2.58 µg/l) was significantly lower than that of normal control group (7.15 ± 6.60 µg/l) (P ˂ 0.05). In addition, whole blood level of molybdenum in patients with metabolic syndrome and type 2 diabetes (5.83 ± 3.94 µg/l) was lower than that of normal group and higher than that of patients with metabolic syndrome without type 2 diabetes (P ˂ 0.05 for both).Conclusion: Our results revealed that metabolic syndrome alters the level of molybdenum in patients. Molybdenum level in patients type 2 diabetes was lower than normal subjects. Therefore, the molybdenum level could be correlated to metabolic syndrome and diabetes. Molybdenum is known to mimic insulin effects, so consumption of foods rich in molybdenum or prescription of molybdenum-containing supplements in the cases of deficiency could be useful.

Keywords

References

  1. Ghotboddin SH, Bahadoran Z, Mirmiran P, Nakhoda K, Azizi F. The association between dairy intake and its nutrients with metabolic syndrome and its components: Review article. Iran J Endocrinol Metab 2014; 16(2): 136-43. [In Persian].
  2. Esteghamati A, Hafezi-Nejad N, Sheikhbahaei S, Heidari B, Zandieh A, Ebadi M, et al. Risk of coronary heart disease associated with metabolic syndrome and its individual components in Iranian subjects: a matched cohort study. J Clin Lipidol 2014; 8(3): 279-86.
  3. Pratyush DD, Tiwari S, Singh S, Singh SK. Risk factors of diabetes in North Indians with metabolic syndrome. Diabetes Metab Syndr 2016; 10(2 Suppl 1): S68-S71.
  4. Sun L, Yu Y, Huang T, An P, Yu D, Yu Z, et al. Associations between ionomic profile and metabolic abnormalities in human population. PLoS One 2012; 7(6): e38845.
  5. Granados-Silvestre ML, Ortiz-Lopez MG, Montufar-Robles I, Menjivar-Iraheta M. Micronutrients and diabetes, the case of minerals. Cir Cir 2014; 82(1): 119-25. [In Spanish].
  6. Akhuemokhan IK, Eregie A, Fasanmade OA. Diabetes prevention and management: the role of trace minerals. African Journal of Diabetes Medicine 2013; 21(2): 37-41.
  7. Burtis CA, Bruns DE. Tietz fundamentals of clinical chemistry and molecular diagnostics. 7th ed. Philadelphia, PA: Saunders; 2014.
  8. Turnlund JR, Keyes WR, Peiffer GL, Chiang G. Molybdenum absorption, excretion, and retention studied with stable isotopes in young men during depletion and repletion. Am J Clin Nutr 1995; 61(5): 1102-9.
  9. Burguera JL, Burguera M. Molybdenum in human whole blood of adult residents of the Merida State (Venezuela). J Trace Elem Med Biol 2007; 21(3): 178-83.
  10. Ojeda AG, Wrobel K, Escobosa AR, Elguera JC, Garay-Sevilla ME, Wrobel K. Molybdenum and copper in four varieties of common bean (Phaseolus vulgaris): new data of potential utility in designing healthy diet for diabetic patients. Biol Trace Elem Res 2015; 163(1-2): 244-54.
  11. Rovenko BM, Perkhulyn NV, Lushchak OV, Storey JM, Storey KB, Lushchak VI. Molybdate partly mimics insulin-promoted metabolic effects in Drosophila melanogaster. Comp Biochem Physiol C Toxicol Pharmacol 2014; 165: 76-82.
  12. Pandey G, Jain GC, Mathur N. Therapeutic potential of metals in managing diabetes mellitus: a review. J Mol Pathophysiol 2012; 1(1): 63-76.
  13. Ozcelikay AT, Becker DJ, Ongemba LN, Pottier AM, Henquin JC, Brichard SM. Improvement of glucose and lipid metabolism in diabetic rats treated with molybdate. Am J Physiol 1996; 270(2 Pt 1): E344-E352.
  14. Alberti KG, Zimmet P, Shaw J. Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 2006; 23(5): 469-80.
  15. Diagnosis and classification of diabetes mellitus. Diabetes Care 2013; 36(Suppl 1): S67-S74.
  16. Marjani A, Ali Akbari F, Eshghinia S. Association between trace elements and metabolic syndrome among type 2 diabetes mellitus patients in Gorgan. Asian J Pharm Clin Res 2015; 8(3): 358-62.
  17. Mozaffary A, Asgari S, Tohidi M, Kazempour-Ardebili S, Azizi F, Hadaegh F. Change in fasting plasma glucose and incident type 2 diabetes mellitus: results from a prospective cohort study. BMJ Open 2016; 6: e010889.
  18. Maanvizhi S, Boppana T, Krishnan C, Arumugam G. Metal complexes in the management of diabetes mellitus: A new therapeutic strategy. Int J Pharm Pharm Sci 2014; 6(7): 40-4.
  19. Ajibola RS, Ogundahunsi OA, Soyinka OO, Ogunyemi EO, Odewabi AO. Serum chromium, molybdenum, zinc and magnesium levels in diabetes mellitus patients in Sagamu, South West Nigeria. Asian J Med Sci 2014; 6(2): 15-9.
  20. Rotter I, Kosik-Bogacka D, Dolegowska B, Safranow K, Lubkowska A, Laszczynska M. Relationship between the concentrations of heavy metals and bioelements in aging men with metabolic syndrome. Int J Environ Res Public Health 2015; 12(4): 3944-61.
  21. Flores CR, Puga MP, Wrobel K, Garay Sevilla ME, Wrobel K. Trace elements status in diabetes mellitus type 2: possible role of the interaction between molybdenum and copper in the progress of typical complications. Diabetes Res Clin Pract 2011; 91(3): 333-41.
  22. Al-Saleh E, Nandakumaran M, Al-Shammari M, Makhseed M, Sadan T, Harouny A. Maternal-fetal status of copper, iron, molybdenum, selenium and zinc in insulin-dependent diabetic pregnancies. Arch Gynecol Obstet 2005; 271(3): 212-7.
  23. Manuti JK, Al-Rubaye FG, Khudhair MS. Serum concentration of molybdenum in chronic renal failure patients requiring hemodialysis. Fac Med Baghdad 2011; 53(4): 393-5.
  24. Giussani A. A recycling systemic model for the biokinetics of molybdenum radionuclides. Sci Total Environ 2008; 404(1): 44-55.
  25. Ghaffari T, Nouri M, Saei AA, Rashidi MR. Aldehyde and xanthine oxidase activities in tissues of streptozotocin-induced diabetic rats: effects of vitamin E and selenium supplementation. Biol Trace Elem Res 2012; 147(1-3): 217-25.
  26. Peredo HA, Andrade V, Donoso AS, Lee HJ, Puyo AM. Sodium molybdate prevents hypertension and vascular prostanoid imbalance in fructose-overloaded rats. Auton Autacoid Pharmacol 2013; 33(3-4): 43-8.
  27. Tolou Ghamari Z, Mehavari Habibabadi J, Palizban AA. Evidence-Based Pharmacotherapy of Epilepsy. Arch Neurosci 2015; 2(1): e18468.
  28. Tolou-Ghamari Z, Palizban AA. Laboratory Monitoring of Cyclosporine. Pre-dose Concentration (C0) After Kidney. Transplantation in Isfahan. Iran J Med Sci 2003; 28(2): 81-5.
Journal of Isfahan Medical School
Volume 35, Issue 429 - Serial Number 429
March and April 2017
Pages 503-510

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History

  • Receive Date: 21 January 2017
  • Revise Date: 02 November 2024
  • Accept Date: 06 April 2022

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