Effects of Aerobic Training, Extract of Althaea kurdica and Noise Stress on the Anxiety-related Behaviors, Plasma Levels of Nitric Oxide and Serotonin in Wistar Male Rats

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Physical Education, School of Education and Psychology, University of Sistan and Bluchestan, Zahedan, Iran

2 Associate Professor, Department of Physical Education, School of Physical Education and Sport Science, Bu-Ali Sina University, Hamadan, Iran

3 Assistant Professor, Department of Physical Education and Sport Science, School of Literature and Humanities, Malayer University, Hamadan, Iran

Abstract

Background: Physical activity and medicinal plants have been used years for the treatment of different neuropsychological diseases such as anxiety. This study aimed to assess the effects of training, Althaea kurdica extract injection, and noise stress on the anxiety-related behaviors, plasma levels of nitric oxide and serotonin in Wistar male rats.Methods: Thirty-five male rats were randomly divided into five groups of seven, noise, training + noise, extract + noise, training + noise + extract, and control groups. The aerobic training was performed 5 days per week, for a 60-day period. The noise stress included exposure to traffic noise 5 hours per day over a 60-day period (range: 95 ± 15 dB). The Althaea curdica extract (500 mg/kg of body weight) was injected intraperitoneally (IP) 30 minutes prior to the plus maze test. The control group was not exposed to any noise or exercise, and was kept away from the sources of stress; the rats were kept under the same conditions. At the end of the experiment, blood samples were collected and plasma nitric oxide (NO) and serotonin concentrations were determined with special kits for rat. For the statistical data analysis, ANOVA and Tukey post-hoc tests were used  at the significant level of P ≤ 0.05.Findings: In the noise + training + extract group, the anxiety was less and nitric oxide and serotonin were more than that of the noise stress group compared with the control group (P < 0.01).Conclusion: It seems that aerobic training and extract injections had eliminated the effect of noise stress, and apparently the effect of aerobic training was more significant than that of the extracts.

Keywords

References

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Journal of Isfahan Medical School
Volume 33, Issue 357 - Serial Number 357
September and October 2016
Pages 1843-1850

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History

  • Receive Date: 29 July 2014
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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