Assessing the Effect of in-vitro Soft Tissue Thickness on Bone Mineral Density Using Dual-Energy X-ray Absorptiometry

Document Type : Original Article (s)

Authors

1 Associate Professor, Biosensor Research Center AND Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences AND Isfahan Osteoporosis Diagnosis Center, Isfahan, Iran

2 MSc Student, Department of Medical Physics, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

3 Isfahan Osteoporosis Diagnosis Center, Isfahan, Iran

4 Associate Professor, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Bone mineral density (BMD) assessment by using dual-energy X-ray absorptiometry (DXA) plays an important role in diagnosis and treatment of osteoporosis. Variation in soft tissue thickness may cause probability errors in DXA bone values. The aim of this study was to assess the effect of soft tissue thickness on bone mineral.Methods: A spine phantom consisting of bone and soft tissue equivalents (Aluminum and Perspex respectively) was made to simulate different status of bone (normal, osteopenia and osteoporosis) and abdominal thicknesses. BMD measurements were performed by DXA using a Norland XR-46 on 45 patients. The statistical analysis for determining the BMD, bone mineral content (BMC), bone area (BA) measurements was done using SPSS software.Findings: According to Pearson correlation test, variation of soft tissue thickness had no statistically significant relation on BMD, BMC and BA (P > 0.05). But non-parametric regression determined soft tissue thickness had some effect on BMD and BMC (P < 0.05), but no statistically effect on BA (P > 0.05).Conclusion: Variation of soft tissue thickness had no considerable effect (less than1%) on bone mineral results, so errors arising from soft tissue thickness in DXA are negligible

Keywords

References

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Journal of Isfahan Medical School
Volume 34, Issue 378 - Serial Number 378
March and April 2016
Pages 347-354

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History

  • Receive Date: 13 December 2015
  • Revise Date:
  • Accept Date: 06 April 2022

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