Renal Function after Renal Transplantation in Patients with Metabolic Syndrome

Document Type : Original Article (s)

Authors

1 Professor, Isfahan Kidney Diseases Research Center AND Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Associate Professor, Isfahan Kidney Diseases Research Center AND Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Professor, Department of Biostatistics and Epidemiology, School of Health, Isfahan University and Medical Sciences, Isfahan, Iran

5 Specialist in Community and Preventive Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

6 Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Recently, renal transplantation has increased worldwide. The incidence of metabolic syndrome is common after renal transplantation that might reduce renal function and increase cardiovascular complications. In this study, we compared renal function after renal transplantation in patients with or without metabolic syndrome.Methods: This cohort prospective study was conducted in 2017 among patients with renal transplantation aged more than 20 years in Isfahan City, Iran. Metabolic syndrome criteria including blood pressure, fasting blood sugar, high- and low-density lipoprotein, triglyceride, and waist circumference, as well as serum creatinine were measured in 30 patients with metabolic syndrome and 30 without metabolic syndrome in one-year follow-up period.Findings: 17 patients were women and 43 were men. The mean serum creatinine changes were not significantly different among the patients with or without metabolic syndrome (P = 0.227) in 1-year follow up. There was no significant association between serum creatinine level with metabolic syndrome criteria such as waist circumference (P = 0.214), diastolic blood pressure (P = 0.061), triglyceride (P = 0.409), high-density lipoprotein (P = 0.315), and fasting blood sugar (P = 0.284) in patients with metabolic syndrome, and only the association between serum creatinine level and systolic blood pressure was significant (P = 0.008).Conclusion: Serum creatinine did not increase significantly in patients with metabolic syndrome. We recommend to consider longer follow-up periods in future studies.

Keywords

References

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Journal of Isfahan Medical School
Volume 36, Issue 495 - Serial Number 495
July and August 2018
Pages 1057-1063

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History

  • Receive Date: 10 September 2018
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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