Effects of Averrhoa Carambola Hydro-alcoholic Extract on Acute Lead-Acetate-Induced Liver Toxicity in Rats

Document Type : Original Article (s)

Authors

1 Student of Veterinary Medicine, School of Veterinary Medicine, University of Zabol, Zabol, Iran

2 Assistant Professor, Department of Basic Science, School of Veterinary Medicine, University of Zabol, Zabol, Iran

3 Assistant Professor, Department of Pathobiology, School of Veterinary, University of Zabol, Zabol, Iran

4 Assistant Professor, Department of Chemistry, School of Basic Science, University of Zabol, Zabol, Iran

5 Associate Professor, Department of Biology, School of Science, Bu Ali Sina University, Hamadan, Iran

Abstract

Background: In this survey, the effect of Averrhoa carambola fruit hydro-alcoholic extract on acute lead-acetate-induced hepatotoxicity in rats was studied.Methods: In this experimental study, 24 male rats were equally divided to 4 groups. The first group received normal saline orally and served as negative control, the second group received only lead acetate for 5 days and served as positive control group. Groups 3 and 4 were treated orally with Averrhoa carambola at doses of 100 and 200 mg/kg, respectively, for 10 days. These groups were also received lead acetate (25 mg/kg) during the last 5 days. At the end of the study, serum liver enzymes and malondialdehyde (MDA) levels were assayed. Besides, histopathological changes of liver were examined under light microscopy.Findings: Oral administration of Averrhoa carambola fruit extract at a dose of 100 mg/kg had no significant effect on serum levels of malondialdehyde and liver enzymes compared to positive control group. Treatment with Averrhoa carambola fruit extract at dose of 200 mg/kg significantly reduced serum levels of alanine transaminase (ALT) (P < 0.05) and aspartate transaminase (AST) (P < 0.01) in rats compared to positive control group. Furthermore, treatment with Averrhoa carambola fruit extract (200 mg/kg) significantly decreased serum levels of malondialdehyde compared with the positive control group (P < 0.01). The histopathological investigations revealed that treatment with Averrhoa carambola fruit extract (200 mg/kg) decreased hepatic necrosis and sinusoidal distention compared to negative control group.Conclusion: Results showed the protective effect of Averrhoa carambola fruit extract on acute lead-acetate-induced liver injury in rats.

Keywords

References

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Journal of Isfahan Medical School
Volume 34, Issue 411 - Serial Number 411
November and December 2017
Pages 1531-1536

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History

  • Receive Date: 18 January 2017
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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