Comparing Pituitary MRI Findings in Patients with Thalassemia with and without Delayed Puberty

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

2 Assistant Professor, Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

3 Resident, Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

4 Assistant Professor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Background: β-thalassemia major is among the most common genetic disorders in Iran. Blood transfusion, as the main stem of management of these patients, has numerous side effects including iron overload. Delayed puberty as a major complication of these patients is multifactorial but seems to be mainly secondary to iron deposition within pituitary gland. This study was designed to compare pituitary MRI signal changes in thalasemia patients with and without delayed puberty.Methods: From β-thalassemia patients, 27cases between 15-25 years were included, 13 with delayed and 14 with normal puberty (according to clinical exam). Pituitary MRI was done, then signal and dimensions of gland was determined and compared by statistical analysis between two groups.Finding: Decreased signal of any degree was detected in 93% of patients. Normal signal and also mild and moderate hyposignality showed no significant difference between two groups (P = 0.317, 0.083, and 0.655, respectively), but severe hyposignality was higher in delayed puberty group (P = 0.034). Also, decreased volume and height of gland was significantly higher among delayed puberty group (P = 0.002 and 0.006 respectively).Conclusion: MRI could be appropriate for diagnosis of delayed puberty in patients with β-thalassemia.

Keywords

References

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Journal of Isfahan Medical School
Volume 28, Issue 114 - Serial Number 114
September and October 2011
Pages 812-818

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History

  • Receive Date: 07 January 2011
  • Revise Date: 02 November 2024
  • Accept Date: 06 April 2022

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