The Effect of Midazolam on the Duration on Lidocaine Interathecal Block

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Anesthesiology, School of Medicine, Isfahan, University of Medical Sciences, Isfahan, Iran.

2 Medical Student, Isfahan, University of Medical Sciences, Isfahan, Iran.

Abstract

Background: One of the issues anesthesia specialists permanently are faced with in spinal blocks is the prolongation of the surgery more what had been estimated. Provided that intravenous midazolam can increase duration of lidocaine interathecal block, it would solve the problem.Methods: This was a double-blind clinical trial study in which adults underwent elective abdominal surgery and lower extremities of ASA, I, II and studied in two 18-member groups. Midazolam group (0.03 mg/kg) underwent the intervention as Midazolam 2mg + fentanyl 1μg/kg (5 min after administration of midazolam) and the control group as normal saline 2cc + fentanyl 1μg/kg (5 min after administration of normal saline). The highest level of sensory block, duration of sensory block, duration of motor (movement) block and recovery duration were measured and documented.Finding: Mean duration of sensory block had no significant difference between the two groups; however, duration of motor block for the Midazolam group was 82.9 ± 27.3 minutes which significantly was more than control group with 59.1 ± 26.5 minutes (P = 0.01). The median of sensory block level for midazolam and control groups respectively were T8 and T10 and according to nonparametric median test, the median of sensory block level had a significant difference in the two groups (P = 0.02). The average duration of stay in the recovery, in the patients of midazolam group was 116.1 ± 29.6 minutes and in the control group also was 87.8 ± 24.1 minutes which significantly it was higher in midazolam group (P = 0.002).Conclusion: The present study indicated that intravenous midazolam injection in spinal anesthesia with lidocaine increased the duration of motor block without any side effects (nausea, vomiting and respiratory distress), and caused more hemodynamic and saturation loss of arterial blood pressure.

Keywords

References

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Journal of Isfahan Medical School
Volume 28, Issue 118 - Serial Number 118
November and December 2011
Pages 1296-1303

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History

  • Receive Date: 19 March 2011
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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