Comparison of the Effect of Ginger and Metoclopramide in Prevention of Nausea and Vomiting after Cholecystectomy

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Anesthesiology, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran

2 Assistant Professor, Department of Community Medicine, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran

3 General Practitioner, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran

4 Assistant Professor, Department of Nephrology, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran

5 Assistant Professor, Department of Basic Sciences, School of Medicine AND Neurosciences Research Center, Torbat Heydarieh University of Medical Sciences, Torbat Heydarieh, Iran

Abstract

Background: Nausea and vomiting are common and troublesome complication after the surgery. Although several medications as prophylactic or therapeutic are used in relation to this problem, but neither of them could not completely suppress and have numerous side effects. This study was performed to compare the prophylactic efficacy of ginger and metoclopramide in reducing nausea and vomiting after cholecystectomy.Methods: 90 patients undergoing cholecystectomy that met the inclusion criteria were divided randomly into two groups (n = 45). Before starting the operation, first group received ginger and the second group received metoclopramide. Thereafter, the severity and duration of nausea and vomiting after first and second hour of surgery was measured via visiting and self-designed questionnaire. Data were analyzed using chi-square test via SPSS20 software at the significant level of P < 0.05.Findings: The two groups were not significantly different in terms of age (P = 0.18), weight (P = 0.07) and gender (P = 0.82). The two groups were divided into two subgroups of less or equal to 60 years of age [33 (55%) and 27 members (45%) in ginger and metoclopramide groups, respectively) and more than 60 years of age [12 members (40%) in ginger and 18 members (60%) in metoclopramide group). In terms of body weight, the two groups were divided into three subgroups of less than 70 kg [6 (85.7%) and 1 patient (14.3%) in ginger and metoclopramide groups, respectively], 70 to 90 kg [36 (45.6%) and 43 patients (54.4%) in ginger and metoclopramide groups, respectively] and more than 90 kg [3 (75%) and 1 patient (25%) in ginger and metoclopramide groups, respectively]. In terms of gender, patients were divided into two subgroups of men [28 (49.1%) and 29 patients (50.9%) in ginger and metoclopramide groups, respectively] and women [17 (51.5%) and 16 patients (48.5%) in ginger and metoclopramide groups, respectively]. The severity of nausea and vomiting at the first hours after the surgery in the group receiving ginger decreased more than the group who received metoclopramide.Conclusion: Ginger reduced incidence of nausea and vomiting more than metoclopramide during the postoperative period. It can be used as a supportive treatment in the prevention of nausea and vomiting.

Keywords

References

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Journal of Isfahan Medical School
Volume 34, Issue 400 - Serial Number 400
July and August 2016
Pages 1121-1127

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History

  • Receive Date: 12 June 2016
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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