Inflammation and Angiogenesis: Role of Inflammatory Cells and Mediators

Document Type : Review Article

Authors

1 Associate Professor, Department of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

2 Professor, Neurogenic Inflammation Research Center AND Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Inflammation is not only a protective mechanism during tissue injury, but also has a key role in tissue repair. Cytokines and growth factors which are released during inflammation are critical for tissue repair and one of the well-known angiogenic factors is vascular endothelial growth factor. Angiogenesis involves endothelial cells as well as inflammatory cells which release several angiogenic factors. Hypoxia is the most important stimulator for inflammation and angiogenesis. Some of the inflammatory mediators are directly and/or indirectly alter angiogenesis and on the other hand, some of angiogenic factors have inflammatory effects. Therefore, it seems that there is a close relationship between angiogenesis and inflammation. This review evaluated the relationship between inflammation and angiogenesis and the role of inflammatory cells and mediators in angiogenesis process.

Keywords

References

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Journal of Isfahan Medical School
Volume 34, Issue 384 - Serial Number 384
March and April 2016
Pages 612-622

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History

  • Receive Date: 10 April 2016
  • Revise Date: 02 November 2024
  • Accept Date: 06 April 2022

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