Comparison of the Effect of Running and Swimming on Some Liver Enzymes of Male Rats Induced by Doxorubicin

Document Type : Original Article(s)

Authors

1 Faculty Member of Behbahan Khatam Alanbia University of Technology, Behbahan, Iran

2 Behbahan Faculty of Medical Science, Behbahan, Iran

3 Behbahan Khatam Alanbia University of Technology, Behabahan, Iran

4 Department of Statistics, Faculty of Data and Energy Sciences Behbahan Khatam Alanbia University of Technology, Behabahan, Iran

Abstract

Background: Various exercises have been studied to reduce the complications caused by the use of doxorubicin and other chemotherapy drugs on healthy body organs; But a limited number of these studies have compared the effect of different sports programs; Therefore, the aim of this study is to compare running and swimming on some liver enzymes of rats induced by doxorubicin.
Methods: 36 adult male desert mice weighing 230 to 280 grams were randomly divided into 6 groups of 6: resting sham (SH), treadmill sham (SHT), swimming sham (SHS), doxorubicin rest (D), doxorubicin treadmill (DT), doxorubicin swimming (DS) were divided. The sports groups did the exercise program 5 sessions a week for 6 weeks. 24 hours after the last exercise session, blood was taken from the left ventricle of the animal with a syringe. To analyze the data, descriptive analysis and one-way analysis of variance, ANOVA and Tukey's post hoc test at a significance level of 0.05.
Findings: Doxorubicin injection caused a significant increase in ALP, SGPT, and SGOT enzymes, both running and swimming exercises caused a significant decrease in ALP, SGPT, and SGOT enzymes, but there was no significant difference between the running and swimming groups on the reduction of the studied enzymes.
Conclusion: Based on the results of the present study, it seems that endurance sports activities are a good way to reduce hepatotoxicity caused by doxorubicin injection in cancer patients, and none of the swimming and running exercises are preferable to the other.

Keywords

Main Subjects

References

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Journal of Isfahan Medical School
Volume 42, Issue 762
2nd Week, June
May and June 2024
Pages 248-255

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History

  • Receive Date: 03 July 2024
  • Accept Date: 09 July 2024

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