Detection of IVSII-1 Mutation of Beta Globin Gene in Carriers of Thalassemia Minor Using High-Resolution Melting Analysis

Document Type : Original Article (s)

Authors

1 Department of Genetics, School of Basic Sciences, Shahrekord University, Shahrekord, Iran

2 Assistant Professor, Department of Genetics, School of Basic Sciences AND Research Institute of Biotechnology, Shahrekord University, Shahrekord, Iran

3 Associate Professor, Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Assistant Professor, Applied Physiology Research Center AND Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease AND Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Beta-thalassemia is one of the most common autosomal recessive disorders in the world population caused by more than 200 different mutations in the beta-globin chain. It is clinically classified as minor, intermediate and major. Beta-thalassemia is the most common monogenic disease in the Mediterranean countries, Middle East, Indian Subcontinent, and Southeast Asia and one of the widespread hereditary disorders in Iran. Among different

Keywords

References

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Journal of Isfahan Medical School
Volume 33, Issue 363 - Serial Number 363
November and December 2016
Pages 2179-2186

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History

  • Receive Date: 14 September 2015
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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