Comparison of the Acute Response of Some Inflammatory Markers to Circular Resistance Training in Fasting in the Morning and Evening in Obese Men

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Physical Education and Sport Sciences, School of Human Sciences, University of Neyshabur, Neyshabur, Iran

2 Associate Professor, Department of Physiology, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran

3 Assistant Professor, Departments of Physiology and Pharmacology, School of Medicine AND Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran

Abstract

Background: Studies has shown that the time-of-day of exercise can have different effects on inflammatory parameters. The aim of the present study was to compare the acute responses of some of inflammatory indicators [C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6)] to acute bouts of circle resistance exercise at different times of the day (morning vs. evening) in obese men.Methods: In the quasi-experimental study, 15 healthy obese men with mean age of 23.84 ± 1.64 years and mean body mass index (BMI) of 31.31 ± 0.20 kg/m2 performed circle resistance exercise in the morning (8 am) on one day; after two weeks, they performed the same circle resistance training session at evening (5 pm). Blood samples were collected to determine CRP, TNF-α and IL-6 at pre-exercise, immediately post exercise, and 2 hours post exercise. Repeated measures analysis of variance (ANOVA) was used to analyze the data.Findings: In both morning and evening, the concentrations of CRP, TNF-α, and IL-6 were significantly increased immediately after exercise (P < 0.010). Concentrations of CRP, TNF-α immediately and 2 hours after resistance exercise were significantly higher in the morning than the evening (P < 0.050). There was no significant difference in IL-6 concentrations responses between morning and evening exercise.Conclusion: The findings of the present study showed that a bout of circle resistance exercise in the morning compared to evening time significantly increased post-exercise CRP and TNF-α parameters, but there was no difference in IL-6 response to exercise between the two conditions.

Keywords

References

  1. Hower IM, Harper SA, Buford TW. Circadian rhythms, exercise, and cardiovascular health. J Circadian Rhythms 2018; 16: 7.
  2. Shanmugam V, Wafi A, Al-Taweel N, Büsselberg D. Disruption of circadian rhythm increases the risk of cancer, metabolic syndrome and cardiovascular disease. Journal of Local and Global Health Science 2013; 2013(1): 3.
  3. Atkinson G, Jones H, Ainslie PN. Circadian variation in the circulatory responses to exercise: Relevance to the morning peaks in strokes and cardiac events. Eur J Appl Physiol 2010; 108(1): 15-29.
  4. Del GM, Gangestad SW. Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. Brain Behav Immun 2018; 70: 61-75.
  5. Calle MC, Fernandez ML. Effects of resistance training on the inflammatory response. Nutr Res Pract 2010; 4(4): 259-69.
  6. Ridker PM, Rifai N, Stampfer MJ, Hennekens CH. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 2000; 101(15): 1767-72.
  7. Bandara WMMS Rathnayake AJIS. Morning vs evening exercises: Which gives a better outcome? EC Emergency Medicine and Critical Care 2019; 3.9: 601-9.
  8. Kim HK, Konishi M, Takahashi M, Tabata H, Endo N, Numao S, et al. Effects of acute endurance exercise performed in the morning and evening on inflammatory cytokine and metabolic hormone responses. PLoS One 2015; 10(9): e0137567.
  9. Pledge D, Grosset JF, Onambele-Pearson GL. Is there a morning-to-evening difference in the acute IL-6 and cortisol responses to resistance exercise? Cytokine 2011; 55(2): 318-23.
  10. Jackson AS, Pollock ML. practical assessment of body composition. Phys Sportsmed 1985; 13(5): 76-90.
  11. Molanouri S, Agha Alinejad H, Amani Shalamzari S, Aghayari A, Asghari Jafarabadi M, Talebi Badrabadi K. Anti-inflammatory effects of a bout of circuit resistance exercise with moderateintensity in inactive obese males. J Shahid Sadoughi Univ Med Sci 2011; 19(5): 598-609. [In Persian].
  12. Bizheh N, Jaafari M. The effect of a single bout circuit resistance exercise on homocysteine, hs-crp and fibrinogen in sedentary middle aged men. Iran J Basic Med Sci 2011; 14(6): 568-73.
  13. Markovitch D, Tyrrell RM, Thompson D. Acute moderate-intensity exercise in middle-aged men has neither an anti- nor proinflammatory effect. J Appl Physiol (1985) 2008; 105(1): 260-5.
  14. Black S, Kushner I, Samols D. C-reactive Protein. J Biol Chem 2004; 279(47): 48487-90.
  15. Brown WM, Davison GW, McClean CM, Murphy MH. A systematic review of the acute effects of exercise on immune and inflammatory indices in untrained adults. Sports Med Open 2015; 1(1): 35.
  16. Lyngso D, Simonsen L, Bulow J. Interleukin-6 production in human subcutaneous abdominal adipose tissue: the effect of exercise. J Physiol 2002; 543(Pt 1): 373-8.
  17. Rosa JS, Oliver SR, Flores RL, Ngo J, Milne GL, Zaldivar FP, et al. Altered inflammatory, oxidative, and metabolic responses to exercise in pediatric obesity and type 1 diabetes. Pediatr Diabetes 2011; 12(5): 464-72.
  18. dos Santos CC, Faria WF, Sasaki JE, Elias RMG, Neto AS. Acute effects of physical exercise at different intensities on inflammatory markers in obese adolescents. J Phys Educ 2019; 30: e3014.
  19. Izquierdo M, Ibanez J, Calbet JA, Navarro-Amezqueta I, Gonzalez-Izal M, Idoate F, et al. Cytokine and hormone responses to resistance training. Eur J Appl Physiol 2009; 107(4): 397-409.
  20. Miles MP, Keller JM, Kordick LK, Kidd JR. Basal, circadian, and acute inflammation in normal versus overweight men. Med Sci Sports Exerc 2012; 44(12): 2290-8.
  21. Izawa S, Miki K, Liu X, Ogawa N. The diurnal patterns of salivary interleukin-6 and C-reactive protein in healthy young adults. Brain Behav Immun 2013; 27(1): 38-41.
  22. DeRijk R, Michelson D, Karp B, Petrides J, Galliven E, Deuster P, et al. Exercise and circadian rhythm-induced variations in plasma cortisol differentially regulate interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor-alpha (TNF alpha) production in humans: high sensitivity of TNF alpha and resistance of IL-6. J Clin Endocrinol Metab 1997; 82(7): 2182-91.
  23. Yamanaka Y, Motoshima H, Uchida K. Hypothalamic-pituitary-adrenal axis differentially responses to morning and evening psychological stress in healthy subjects. Neuropsychopharmacol Rep 2019; 39(1): 41-7.
  24. Black PH, Garbutt LD. Stress, inflammation and cardiovascular disease. J Psychosom Res 2002; 52(1): 1-23.
Journal of Isfahan Medical School
Volume 37, Issue 560 - Serial Number 560
November and December 2020
Pages 1440-1447

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History

  • Receive Date: 24 December 2019
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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