Antihypertensive Effect of Lactoferrin on Dexamethasone-Induced Hypertension in Rat

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences AND Isfahan Pharmaceutical Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Pharmacy, School of Pharmacy and Pharmaceutical Sciences AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Dexamethasone-induced hypertension is one of the animal models of hypertension. Lactoferrin is a natural iron-binding protein with proposed antihypertensive effects. In this study, the effect of chronic use of lactoferrin was investigated on dexamethasone-induced hypertension in rat and compared with captopril.Methods: In this experimental study, hypertension was induced by subcutaneously injection of dexamethasone (30 µg/kg/day) for 15 days in Wistar rat. Lactoferrin (300 mg/kg) and captopril (40 mg/kg) were orally given from the day 8 to 15. Systolic blood pressure was measured by tail cuff. Body weight was measured during experiment and thymus weight was detected as a marker of glucocorticoid activity at the end of study.Findings: Administration of dexamethasone increased systolic blood pressure (115.6 + 3.3 to 150.1 + 7.4 mmHg) and decreased body and thymus weight (P < 0.05). Chronic administration of lactoferrin and captopril for one week decreased systolic blood pressure (P < 0.01 for both). Lactoferrin also prevented body weight loss.Conclusion: The results indicated antihypertensive effect of lactoferrin on dexamethasone-induced hypertension. Further studies are suggested for finding the mechanism of lactoferrin in this model of hypertension. 

Keywords

References

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Journal of Isfahan Medical School
Volume 31, Issue 245 - Serial Number 245
May and June 2013
Pages 1096-1104

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History

  • Receive Date: 20 July 2013
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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