Diagnostic Values of Troponin I and T for Prediction of Mortality in Patients Hospitalized in Intensive care Unit and Need Hemodialysis in Alzahra Hospital, Isfahan, Iran, during 2015-16

Document Type : Original Article (s)

Authors

1 Assistant Professor, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Resident, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Some of previous studies showed that risk of mortality in patients who need hemodialysis and hospitalized in intensive care unit is higher but and biomarker is not detected for prediction of mortality in these patients. So, this study aimed to evaluate the diagnostic values of troponin I and T for prediction of mortality in patients hospitalized in intensive care unit and need hemodialysis.Methods: In a cross-sectional study in Alzahra hospital, Isfahan, Iran, during 2015-16, 70 patients hospitalized in intensive care unit were selected and serum levels of troponin I and T were measured and its relation with mortality was studied. In addition, the diagnostic values of troponin I and T for prediction of mortality was evaluated.Findings: The best cut-off point of troponin I and T for prediction of mortality were 1.5 and 1.2 µg/ml, respectively. In addition, sensitivity, specificity, false positive, false negative, positive predictive values, negative predictive value and accuracy were 26.7%, 81.8%, 18.2%, 73.3%, 28.6%, 80.4%, and 67.1% for troponin I, respectively, and 26.7%, 78.2%, 21.8%, 73.3%, 25.0%, 79.6%, and 70% for troponin T, respectively.Conclusion: Troponin I and T are not suitable markers for prediction of mortality in patients hospitalized in intensive care units and need hemodialysis.

Keywords

References

  1. Benjamin I, Griggs R, Wing E, Fitz JG. Cecil essentials of medicine (kidney disease). Trans. Najafi I, Arjmand M, Serati Noori I. Teran, Iran: Arjmand Publications; 2010. p. 52-7. [In Persian].
  2. Haghighi AN, Broumand B, D'Amico M, Locatelli F, Ritz E. The epidemiology of end-stage renal disease in Iran in an international perspective. Nephrol Dial Transplant 2002; 17(1): 28-32.
  3. Abaci A, Ekici E, Oguzhan A, Tokgoz B, Utas C. Cardiac troponins T and I in patients with end-stage renal disease: the relation with left ventricular mass and their prognostic value. Clin Cardiol 2004; 27(12): 704-9.
  4. Korff S, Katus HA, Giannitsis E. Differential diagnosis of elevated troponins. Heart 2006; 92(7): 987-93.
  5. Chapelle JP. Cardiac troponin I and troponin T: Recent players in the field of myocardial markers. Clin Chem Lab Med 1999; 37(1): 11-20.
  6. Bahjati M. The role of cardiac troponin in the evaluation of heart attack and chest syndrome. Teb Tazkiyeh 2012; 11(2): 68-73. [In Persian].
  7. Patel ML, Sachan R, Singh P, Chaudhary SC, Sachan P, Gupta P. Prognostic significance of cardiac troponin-T Level in chronic kidney disease patients on hemodialysis. Journal of Integrative Nephrology and Andrology 2014; 1(2): 60-6.
  8. Zeraati AA, Sharifipour F, Rajabigol F, Pourzand H, Beladi Mousavi SS. Correlation between Serum level of troponin I and high sensetive CRP in renal transplant patients. J Birjand Univ Med Sci 2013; 20(3): 312-6. [In Persian].
  9. Hamm CW, Giannitsis E, Katus HA. Cardiac troponin elevations in patients without acute coronary syndrome. Circulation 2002; 106(23): 2871-2.
  10. Mallamaci F, Zoccali C, Parlongo S, Tripepi G, Benedetto FA, Cutrupi S, et al. Troponin is related to left ventricular mass and predicts all-cause and cardiovascular mortality in hemodialysis patients. Am J Kidney Dis 2002; 40(1): 68-75.
  11. Dierkes J, Domrose U, Westphal S, Ambrosch A, Bosselmann HP, Neumann KH, et al. Cardiac troponin T predicts mortality in patients with end-stage renal disease. Circulation 2000; 102(16): 1964-9.
  12. McLaurin MD, Apple FS, Voss EM, Herzog CA, Sharkey SW. Cardiac troponin I, cardiac troponin T, and creatine kinase MB in dialysis patients without ischemic heart disease: evidence of cardiac troponin T expression in skeletal muscle. Clin Chem 1997; 43(6 Pt 1): 976-82.
Journal of Isfahan Medical School
Volume 35, Issue 442 - Serial Number 442
July and August 2017
Pages 1000-1005

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History

  • Receive Date: 29 January 2017
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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