Langerhans Cell Histiocytosis in a Child with Unifocal Mandibular Lesion and Diabetes Insipidus: A Case Report

Document Type : Case Report

Authors

1 Student of Pediatric Endocrinology, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan

2 Professor of Pediatric Endocrinology, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan

Abstract

Background: Patients with Langerhans cell histiocytosis are at particularly high risk for central diabetes insipi-dus (CDI) due to hypothalamic-pituitary disease. Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the proliferation of specialized bone marrow-derived Langerhans cells and mature eosinophils. Three disease variants were included in this description, eosinophilic granuloma, Letterer–Siwe disease and Hand–Schuller–Christian syndrome.

Case Reprort: We report a patient of Langerhans cell histiocytosis-solitary eosinophilic granuloma of the mand-ible that presented with diabetes insipitus after biopsy of mass.

Keywords: Langerhans cell histiocytosis (LCH), Eosinophilic granuloma, Mandible, Diabetes insipidus.

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History

  • Receive Date: 07 November 2010
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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