Relation between Serum Level of Total PSA and Free PSA/Total PSA Ratio with Grade of Prostate Cancer

Document Type : Original Article (s)

Authors

1 Professor, Department of Urology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associate Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Student of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

4 Epidemiologist, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: One of the most common visceral cancers among men in the world is prostate cancer. Screening for early detection has a positive effect on patients’ survival time. Measurement of serum level of total PSA and free PSA is abundantly used for screening and diagnosis of prostate cancer. However, no study has been done to determine the relation between serum level of total PSA and free PSA/total PSA ratio with malignancy degree on biopsy samples. The aim of this study was to determine the relation of serum level of total PSA and free PSA/total PSA ratio, with malignancy degree.Methods: This is a cross-sectional study done in Alzahra Hospital during 2012-2013. We selected 85 patients with prostate cancer whose disease was detected in the pathology ward. Serum level of total PSA and free PSA were measured, and the degree of malignancy was determined by pathology ward based on the Gleason scoring system. All data was recorded in the questionnaire and entered into the computer and analyzed by SPSS software.Findings: The results of this study showed that there is 38% correlation between Gleason score and free PSA/total PSA ratio. Based on the Pearson correlation, this relation was statistically significant (P = 0.037). Moreover, there is a 37% relation between serum level of total PSA and the Gleason score; this relation was statistically significant (P < 0.001).   Conclusion: Prostate cancer is usually detected late and biopsy is rarely accepted by patients. Moreover, serum level of total PSA and total PSA/free PSA ratio has a relation with degree of malignancy. Therefore, serum level of PSA can help patients and physicians in early detection and treatment of prostate cancer.

Keywords

References

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Journal of Isfahan Medical School
Volume 31, Issue 249 - Serial Number 249
July and August 2013
Pages 1305-1313

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History

  • Receive Date: 24 August 2013
  • Revise Date:
  • Accept Date: 06 April 2022

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