Effects of Losartan on Capillary Density in Cardiac Muscles of Diabetic Rats

Document Type : Original Article(s)

Authors

1 Department of Physiology, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran

2 Associate Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Associate Professor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Stimulatory and/or inhibitory effects of angiotensin II is attributed to angiotensin receptor I. A few studies investigated the role of angiotensin receptor I on cardiovascular system in diabetic subjects. In this study, we evaluated the effects of losartan, an angiotensin II receptor I blocker, on myocardial capillary density in diabetic rats. Methods: A total number of 18 male rats were divided into 3 groups of control, diabetic, and diabetic receiving losartan. Diabetes was induced by intraperitoneal injection of streptozotocin (55 mg/kg). A daily dose of 15 mg/kg intraperitoneal losartan was injected to the treatment group. After 21 days, blood samples were taken and myocardial tissue was evaluated by immunohistochemistry. Findings: Myocardial capillary density in diabetic animals was lower than the control group (P ˂ 0.05). Losartan could not significantly change capillary density in myocardial tissue of the diabetic rats (P ˃ 0.05). Conclusion: It seems that losartan administration does not have beneficial effects on myocardial capillary density in diabetic animals. Keywords: Losartan, Angiotensin II, Capillary density, Diabetes

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History

  • Receive Date: 05 February 2012
  • Revise Date:
  • Accept Date: 06 April 2022

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