The Effect of Curcumin Pill in Treatment of Non-alcoholic Fatty Liver Disease: A Clinical Trial Study

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Internal Medicine, School of Medicine AND Isfahan Bone Metabolic Disorders Research Center, Isfahan University of Medical Sciences, Isfahan Iran

2 Resident, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Gastroenterologist, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Science, Isfahan, Iran

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is the most common type of liver disease across the world. Due to the high prevalence of NAFLD, some patients tend to use herbal medicines for its treatment. The aim of the present study was to evaluate the effects of curcumin pill on NAFLD.Methods: In this clinical trial study, 100 patients with NAFLD were enrolled. Then, their height, weight, and body mass index were measured, and liver function tests and liver ultrasound were performed, too. The patients were then divided into two groups of case and control, and received curcumin and placebo for eight weeks, respectively. Before and after intervention, fasting blood sugar (FBS), lipid profile levels [including total cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL)], human C-reactive protein (hCRP) level, and liver markers such as aspartate aminotransferase (AST), alkaline phosphatase (ALP), and alanine transaminase (ALT) were measured and recorded again. Data were analyzed and compared between two groups using SPSS software.Findings: There was no significant difference between the two groups in terms of gender, age, clinical features, total cholesterol, triglyceride, LDL, HDL, FBS, liver function markers such as ALP, ALT, and AST, and hCRP, and fatty liver grade at the onset of the study (P > 0.050). However, the level of ALT, AST, and hCRP significantly reduced in the case group after the intervention (P < 0.001).Conclusion: According to the results of the present study, it seems that curcumin can be recommended for appropriate treatment of NAFLD.

Keywords

References

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Journal of Isfahan Medical School
Volume 37, Issue 538 - Serial Number 538
July and August 2019
Pages 943-949

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History

  • Receive Date: 08 September 2019
  • Revise Date: 02 November 2024
  • Accept Date: 06 April 2022

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