Platelet-Rich Plasma (PRP) Therapy in Skin Rejuvenation: Benefits and Adverse Influences

Document Type : Review Article

Authors

1 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

2 Professor, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan AND Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

3 Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

Abstract

A safe and effective rejuvenation method with few side effects is one of the main purposes of most of the aesthetic procedures. As wound healing process is similar to rejuvenation mechanisms, diverse methods such as ablative and non-ablative laser have been applied to meet this target. A recent method that has remarkably taken experts' and technicians’ attention is platelet-rich plasma (PRP) injection. This article reviews molecular mechanisms of aging and rejuvenation. It also evaluates clinical documents regarding the effects of platelet-rich plasma in rejuvenation beside its possible side effects. Because of high concentration of growth factors in platelet-rich plasma, it potentially can accelerate wound healing. However, there is a concern about the relation between the high level of growth factors and induction of signaling cascades of tumors. Long-term platelet-rich plasma outcomes need to be more investigated in cohort studies.

Keywords

References

  1. Kohl E, Steinbauer J, Landthaler M, Szeimies RM. Skin ageing. J Eur Acad Dermatol Venereol 2011; 25(8): 873-84.
  2. Cho JM, Lee YH, Baek RM, Lee SW. Effect of platelet-rich plasma on ultraviolet b-induced skin wrinkles in nude mice. J Plast Reconstr Aesthet Surg 2011; 64(2): e31-e39.
  3. Kim DH, Je YJ, Kim CD, Lee YH, Seo YJ, Lee JH, et al. Can Platelet-rich Plasma Be Used for Skin Rejuvenation? Evaluation of Effects of Platelet-rich Plasma on Human Dermal Fibroblast. Ann Dermatol 2011; 23(4): 424-31.
  4. Naylor EC, Watson RE, Sherratt MJ. Molecular aspects of skin ageing. Maturitas 2011; 69(3): 249-56.
  5. Banihashemi M, Nakhaeizadeh S. An introduction to application of Platelet Rich Plasma (PRP) in skin rejuvenation. Rev Clin Med 2014; 1(2): 38-43.
  6. Fabi S, Sundaram H. The potential of topical and injectable growth factors and cytokines for skin rejuvenation. Facial Plast Surg 2014; 30(2): 157-71.
  7. Kim SA, Ryu HW, Lee KS, Cho JW. Application of platelet-rich plasma accelerates the wound healing process in acute and chronic ulcers through rapid migration and upregulation of cyclin A and CDK4 in HaCaT cells. Mol Med Rep 2013; 7(2): 476-80.
  8. Cho JW, Kim SA, Lee KS. Platelet-rich plasma induces increased expression of G1 cell cycle regulators, type I collagen, and matrix metalloproteinase-1 in human skin fibroblasts. Int J Mol Med 2012; 29(1): 32-6.
  9. Helbig D, Paasch U. Molecular changes during skin aging and wound healing after fractional ablative photothermolysis. Skin Res Technol 2011; 17(1): 119-28.
  10. Foster TE, Puskas BL, Mandelbaum BR, Gerhardt MB, Rodeo SA. Platelet-rich plasma: from basic science to clinical applications. Am J Sports Med 2009; 37(11): 2259-72.
  11. Eppley BL, Pietrzak WS, Blanton M. Platelet-rich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg 2006; 118(6): 147e-59e.
  12. Akhundov K, Pietramaggiori G, Waselle L, Darwiche S, Guerid S, Scaletta C, et al. Development of a cost-effective method for platelet-rich plasma (PRP) preparation for topical wound healing. Ann Burns Fire Disasters 2012; 25(4): 207-13.
  13. Dohan Ehrenfest DM, Bielecki T, Jimbo R, Barbe G, Del CM, Inchingolo F, et al. Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates? An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte- and platelet-rich fibrin (L-PRF). Curr Pharm Biotechnol 2012; 13(7): 1145-52.
  14. Jaffary F, Nilforoushzadeh MA, Zarkoob H. Patient satisfaction and efficacy of accent radiofrequency for facial skin wrinkle reduction. J Res Med Sci 2013; 18(11): 970-5.
  15. Nilforoushzadeh MA, Jaffary F, Ansari N, Moradi S, Siadat AH. The comparison between trichloroacetic Acid 50% and co(2) laser in the treatment of cutaneous leishmaniasis scar. Indian J Dermatol 2011; 56(2): 171-3.
  16. Nilforoushzadeh MA, Faghihi G, Jafari F, Haftbaradaran E, Hoseini SM, Mazaheri N. Comparison of fractional carbon dioxide laser alone and in combination with subcision in improving atrophic acne scars. J Isfahan Med Sch 2013; 31(226): 131-7. [In Persian].
  17. Nilforoushzadeh MA, Jaffary F, Derakhshan R, Haftbaradaran E. Comparison between intralesional meglumine antimoniate and combination of trichloroacetic acid 50% and intralesional meglumine antimoniate in the treatment of acute Cutaneous lishmaniasis. Skin & Leishmaniasis 2010; 1(1): 18-22.
  18. Prakash S, Thakur A. Platelet concentrates: past, present and future. J Maxillofac Oral Surg 2011; 10(1): 45-9.
  19. Martinez-Zapata MJ, Marti-Carvajal A, Sola I, Bolibar I, Angel EJ, Rodriguez L, et al. Efficacy and safety of the use of autologous plasma rich in platelets for tissue regeneration: a systematic review. Transfusion 2009; 49(1): 44-56.
  20. Langer A, Rogowski W. Systematic review of economic evaluations of human cell-derived wound care products for the treatment of venous leg and diabetic foot ulcers. BMC Health Serv Res 2009; 9: 115.
  21. Kakudo N, Kushida S, Minakata T, Suzuki K, Kusumoto K. Platelet-rich plasma promotes epithelialization and angiogenesis in a splitthickness skin graft donor site. Med Mol Morphol 2011; 44(4): 233-6.
  22. Amable PR, Carias RB, Teixeira MV, da CP, I, Correa do Amaral RJ, Granjeiro JM, et al. Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors. Stem Cell Res Ther 2013; 4(3): 67.
  23. Araki J, Jona M, Eto H, Aoi N, Kato H, Suga H, et al. Optimized preparation method of platelet-concentrated plasma and noncoagulating platelet-derived factor concentrates: maximization of platelet concentration and removal of fibrinogen. Tissue Eng Part C Methods 2012; 18(3): 176-85.
  24. Castillo TN, Pouliot MA, Kim HJ, Dragoo JL. Comparison of growth factor and platelet concentration from commercial platelet-rich plasma separation systems. Am J Sports Med 2011; 39(2): 266-71.
  25. Hamilton B, Tol JL, Knez W, Chalabi H. Exercise and the platelet activator calcium chloride both influence the growth factor content of platelet-rich plasma (PRP): overlooked biochemical factors that could influence PRP treatment. Br J Sports Med 2015; 49(14): 957-60.
  26. Graziani F, Ivanovski S, Cei S, Ducci F, Tonetti M, Gabriele M. The in vitro effect of different PRP concentrations on osteoblasts and fibroblasts. Clin Oral Implants Res 2006; 17(2): 212-9.
  27. Mazzocca AD, McCarthy MB, Chowaniec DM, Cote MP, Romeo AA, Bradley JP, et al. Platelet-rich plasma differs according to preparation method and human variability. J Bone Joint Surg Am 2012; 94(4): 308-16.
  28. Sommeling CE, Heyneman A, Hoeksema H, Verbelen J, Stillaert FB, Monstrey S. The use of platelet-rich plasma in plastic surgery: a systematic review. J Plast Reconstr Aesthet Surg 2013; 66(3): 301-11.
  29. Na JI, Choi JW, Choi HR, Jeong JB, Park KC, Youn SW, et al. Rapid healing and reduced erythema after ablative fractional carbon dioxide laser resurfacing combined with the application of autologous platelet-rich plasma. Dermatol Surg 2011; 37(4): 463-8.
  30. Willemsen JC, van der Lei B, Vermeulen KM, Stevens HP. The effects of platelet-rich plasma on recovery time and aesthetic outcome in facial rejuvenation: preliminary retrospective observations. Aesthetic Plast Surg 2014; 38(5): 1057-63.
  31. Mehryan P, Zartab H, Rajabi A, Pazhoohi N, Firooz A. Assessment of efficacy of platelet-rich plasma (PRP) on infraorbital dark circles and crow's feet wrinkles. J Cosmet Dermatol 2014; 13(1): 72-8.
  32. Mikhael NW, El-Esawy FM. Skin rejuvenation with autologous concentrated platelet-rich plasma. Egypt J Dermatol Venereol 2014; 34(1): 5-9.
  33. Yuksel EP, Sahin G, Aydin F, Senturk N, Turanli AY. Evaluation of effects of platelet-rich plasma on human facial skin. J Cosmet Laser Ther 2014; 16(5): 206-8.
  34. Shin MK, Lee JH, Lee SJ, Kim NI. Platelet-rich plasma combined with fractional laser therapy for skin rejuvenation. Dermatol Surg 2012; 38(4): 623-30.
  35. Redaelli A, Romano D, Marciano A. Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. J Drugs Dermatol 2010; 9(5): 466-72.
  36. Kakudo N, Morimoto N, Kushida S, Ogawa T, Kusumoto K. Platelet-rich plasma releasate promotes angiogenesis in vitro and in vivo. Med Mol Morphol 2014; 47(2): 83-9.
  37. Carter CA, Jolly DG, Worden CE, Sr., Hendren DG, Kane CJ. Platelet-rich plasma gel promotes differentiation and regeneration during equine wound healing. Exp Mol Pathol 2003; 74(3): 244-55.
  38. Nagata MJ, Messora MR, Furlaneto FA, Fucini SE, Bosco AF, Garcia VG, et al. Effectiveness of two methods for preparation of autologous platelet-rich plasma: an experimental study in rabbits. Eur J Dent 2010; 4(4): 395-402.
  39. Senet P, Bon FX, Benbunan M, Bussel A, Traineau R, Calvo F, et al. Randomized trial and local biological effect of autologous platelets used as adjuvant therapy for chronic venous leg ulcers. J Vasc Surg 2003; 38(6): 1342-8.
  40. Witsch E, Sela M, Yarden Y. Roles for growth factors in cancer progression. Physiology (Bethesda ) 2010; 25(2): 85-101.
  41. Goustin AS, Leof EB, Shipley GD, Moses HL. Growth factors and cancer. Cancer Res 1986; 46(3): 1015-29.
  42. Hunter T. The proteins of oncogenes. Scientific Ameriacn 1984; 251(2): 70-9.
  43. Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev 2008; 22(10): 1276-312.
  44. Ziyadeh N, Fife D, Walker AM, Wilkinson GS, Seeger JD. A matched cohort study of the risk of cancer in users of becaplermin. Adv Skin Wound Care 2011; 24(1): 31-9.
  45. Solchaga LA, Hee CK, Roach S, Snel LB. Safety of recombinant human platelet-derived growth factor-BB in Augment((R)) Bone Graft. J Tissue Eng 2012; 3(1): 2041731412442668.
  46. Papanas N, Maltezos E. Benefit-risk assessment of becaplermin in the treatment of diabetic foot ulcers. Drug Saf 2010; 33(6): 455-61.
  47. Labelle M, Begum S, Hynes RO. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 2011; 20(5): 576-90.
Journal of Isfahan Medical School
Volume 33, Issue 343 - Serial Number 343
May and June 2015
Pages 1168-1185

Files

History

  • Receive Date: 02 February 2015
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics