The Comparison of Serum Immunoglobulin G, M, E and A in the Patients with Oral Lichen Planus and Oral Lichenoid (Contact-Drug) Reaction

Document Type : Original Article (s)

Authors

1 Associate Professor, Torabinejad Dental Research Center AND Department of Oral and Maxillofacial Medicine, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

2 Assistant Professor, Torabinejad Dental Research Center AND Department of Oral and Maxillofacial Medicine, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Oral lichenoid reaction is the general nomenclature for explanation of the lesions that have the same clinical and histological appearance. These reactions include lichen planus and oral lichenoid reactions [lichenoid contact reaction, lichenoid drug eruption, and (graft-versus-host disease GVHD)]. This study tried to document the differences between these two groups lesions based on immunological criteria such as immunoglobulins (Ig) G, M, E and A.Methods: The method of this research was descriptive and analytic. The statistical samples included two groups of 25 patients who had lichen planus or lichenoid reactions differentiated from each other via clinical and histopathological criteria of World Health Organization (WHO). 5 cc of blood was taken from each patient. Then, all of the achieved data were analyzed using t and chi-square tests.Findings: The level of IgE increased in two groups, but there was not significant difference between oral lichen planus (OLP) and oral lichenoid reaction (OLR). The level of IgA was increased in oral lichen planus patients (P < 0.05). There were not significant differences between IgG and IgM in two groups.Conclusion: Suggestion of criteria for distinguishing oral lichen planus from oral lichenoid reaction is the first line for obtaining favorable treatment planning for all the patients.

Keywords

References

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Journal of Isfahan Medical School
Volume 33, Issue 335 - Serial Number 335
March and April 2015
Pages 731-738

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History

  • Receive Date: 07 May 2015
  • Revise Date: 02 November 2024
  • Accept Date: 06 April 2022

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