Document Type : Original Article (s)
Authors
1
Professor, Anesthesiology and Critical Care Research Center, Isfahan University of Medical sciences, Isfahan, Iran
2
Resident, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3
Internist, Shahrekord University of Medical Sciences, Shahrekord, Iran
Abstract
Background: This study aimed to compare the effect of adding dexmedmodine and fentanyl to bupivacaine on the adequacy of anesthesia and postoperative pain in lumbar discectomy under spinal anesthesia.Methods: In a clinical trial study, 105 patients who candidate for lumbar discectomy in Kashani hospital in Isfahan, Iran, during the years 2016-17 were selected and randomly divided into three groups of 35 patients. For the spinal block, in the first group, 15 mg Marcaine plus 25 µg/kg fentanyl, in the second group 15 mg Marcaine plus 50 µg/kg dexmedetomidine, and in the third group, 15 mg Marcaine alone was were injected. The adequacy of anesthesia and postoperative pain was compared between the groups during and after the surgery.Findings: The mean postoperative pain in the three groups of Marcaine + fentanyl, Marcaine + dexmedmotidine and Marcaine alone was 5.09 ± 1.5, 4.14 ± 1.1, and 4.89 ± 1.5 (P < 0.001), 4.2 ± 1.5, 3.54 ± 1.2, and 4.54 ±1.5 (P = 0.014), 3.89 ± 1.4, 3.06 ± 0.87, and 4.29 ± 1.6 (P = 0.001), and 4.34 ± 1.3, 2.63 ± 0.88, and 3.8±1.64 (P = 0.001) at 2, 6, 12, and 24 hours after the surgery, respectively, and significant differences were observed between the three groups.Conclusion: The use of the combination of dexmedmotidine and Marcaine in patients undergoing lumbar disc surgery with local anesthesia is accompanied by a reduction in the appropriate postoperative pain, and a greater satisfaction of the patient and the physician.
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