Effect of Methylphenidate on Methadone-Induced Analagesia in Rat

Document Type : Original Article (s)

Authors

1 Student of Medicine, Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran

2 Assistant Professor, Department of Physiology and Pharmacology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

3 Assistant Professor, Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran

Abstract

Background: A known problem of chronic administration of opioid is tolerance to its analgesic effect. Co-administration of a non-opioid analgesic may help reducing the opiate dose and consequently tolerance and dependency. It is reported that repeated use of methylphenidate, one of amphetamines, increased the expression of µ opioid receptor and had antinociception. Therefore, this study aimed to evaluate the effect of methylphenidate on methadone-induced analgesia.Methods: Nine groups of 8 male rats weighting 270 ± 20 g were randomly selected; control group received 1 ml/kg oral normal saline, metylphenidate groups received 5, 10 and 15 mg/kg oral metylphenidate, methadone groups received 5, 10, 20 mg/kg oral methadone, and combined groups received 5 mg/kg methadone +5 or 15 mg/kg methylphenidate orally. Pain was measured using plantar test apparatus.Findings: Only, 15 mg/kg methylphenidate produced significant analgesic effect. In addition, co-administration of non-effective doses of methylphenidate and 5 mg/ kg methadone significantly increased the analgesic effects of methadone at 60 minutes after gavage.Conclusion: We found that methylphenidate potentiate the analgesic effects of methadone in rats.

Keywords

References

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Journal of Isfahan Medical School
Volume 33, Issue 327 - Serial Number 327
January and February 2015
Pages 316-325

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History

  • Receive Date: 29 May 2014
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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