Effect of Exposure to Chronic Heterogeneous Sequential Stress during Prenatal on Formalin-Induced Nociceptive Behaviour in Adult Offspring in Rats

Document Type : Original Article (s)

Authors

1 Professor, Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran

2 Instructor, Department of Nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

3 Assistant Professor, Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran

Abstract

Background: There are different kinds of stress on mothers during prenatal period. The present study investigated the effects of exposure to chronic heterogeneous sequential stress during prenatal period on formalin-induced nociceptive behavior in adult offspring.Methods: In the present study, animals were divided in stressed and non-stressed groups and their offspring divided in male and female groups. Heterogeneous sequential stress including food deprivation, water deprivation, restraint, restraint at room temperature, restraint at 4◦C, forced swimming and social isolation were applied during days 9 to 19 of gestation. Formalin test as chemical model and hot-plate as thermal pain model were used in rats.Findings: Chronic heterogeneous sequential stress increased the nociceptive behaviors in male rats in first part and in female rats in second part of phase 2 of formalin test compared with controls.Conclusion: The result of this study showed that chronic heterogeneous sequential stress in rats increased the nociceptive behaviours in second phase of formalin test in a gender-dependent order; which suggested chronic heterogeneous sequential stress may be useful in evaluating the basic mechanism of exposure to chronic heterogeneous sequential stress during prenatal period on in adult offspring.

Keywords

References

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Journal of Isfahan Medical School
Volume 31, Issue 256 - Serial Number 256
September and October 2013
Pages 1640-1648

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History

  • Receive Date: 18 December 2012
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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