Impact of Vitamin D on Insulin Resistance in Patients with Type ΙΙ Diabetes: A Comprehensive Cohort Design

Document Type : Original Article (s)

Authors

1 MSc Student, Department of Epidemiology and Biostatistics, School of Health AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associate Professor, Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

3 Assistant Professor, Clinical Development Research Center, Qom University of Medical Sciences, Qom, Iran

Abstract

Background: Some observational studies show that the consumption of vitamin D is one of the preventive methods which may potentially be useful in the reduction of diabetes type ΙΙ development, insulin resistance, impaired glucose tolerance, and metabolic syndrome. The purpose of this study was to evaluate the effect of vitamin D on insulin resistance in patients with type II diabetes.Methods: This study was conducted as a comprehensive cohort design in Qom, Iran, in 2012. The participants were 120 patients with type II diabetes of whom, 58 agreed to be randomized into two groups and 62 patients were allocated to their preferences. For randomized treatment group, a pill of vitamin D which contained 50000 units was used weekly and orally for duration of 3 months. In the control group, the placebo pill of vitamin D was prescribed by the same method. In the preferential group, patients received neither vitamin D nor placebo. The value of insulin resistance was defined as a score greater than 3.87 in HOMA-IR (Homeostatic model assessment -estimated insulin resistance) index.Findings: Vitamin D could significantly decrease the HOMA-IR index in the randomized group after controlling for the variables of sex, age, body mass index (BMI), waist, duration of diabetes, heart disease, and HOMA-IR index at the beginning of the study. The reduction was not statistically significant in the preferential group.Conclusion: Vitamin D can affect the reduction of fasting blood sugar (FBS) and insulin resistance in the randomized group but in the preferential group it cannot.

Keywords

References

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Journal of Isfahan Medical School
Volume 31, Issue 239 - Serial Number 239
May and June 2013
Pages 777-791

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History

  • Receive Date: 08 January 2013
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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