Chronic Low-Grade Inflammation: Etiology and its Effects

Document Type : Review Article

Authors

1 MSc Student, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Assistant Professor, Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Professor, Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Chronic low-grade inflammation is a Para-clinical finding in several diseases including obesity, diabetes, nervous diseases and etc. Numerous studies have been done to determine the causes and effects of low-grade inflammation on the body. Today, chronic low-grade inflammation is considered in pathogenesis of these diseases. Chronic inflammation is reflected by increased circulating levels of gram-negative bacterial endotoxin lipopolysaccharide (LPS) which is associated by high level of inflammatory markers. Numerous factors can be involved in induction and progression of low-grade inflammation which lead to some consequences on different parts of body. In this review, we aimed to discuss about the causes and consequences of low-grade inflammation.

Keywords

References

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Journal of Isfahan Medical School
Volume 34, Issue 379 - Serial Number 379
March and April 2016
Pages 408-421

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History

  • Receive Date: 18 October 2015
  • Revise Date: 02 November 2024
  • Accept Date: 06 April 2022

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