Document Type : Original Article(s)
Authors
1
General Surgeon, Master Science of Epidemiology, Department of Surgery, Semnan University of Medical Sciences, Semnan
2
Associate Professor of Statistics, Department of Epidemiology, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz
3
Associate Professor of Surgery, Department of Organ Transplantation, Shiraz University of Medical Sciences, Shiraz
4
Professor of Surgery, Department of Organ Transplantation, Shiraz University of Medical Sciences, Shiraz
Abstract
Background:
The Shiraz Liver Transplant Audit collects information on all liver transplantations that are carried out in Iran. In this paper, we describe these transplantations and their outcomes in adult patients according to the primary liver disease diagnosis, type and period of transplantation.
Methods: A prospective cohort study carried on 364 orthotropic liver transplantations in Shiraz Namazi hospital from June 2002 to July 2008. Actual survival rates, calculated using the Kaplan-Meier method, were compared using the log-rank test. To determine independent prognostic factors for survival, the Cox regression model was used.
Findings:Among the 364 patients included in this study (age range: 13-39 years; 327 [68.1%] men), the most common causes of liver disease were hepatitis B and C virus infection (25.8). Overall patient survival rates at 1, 2, 5 and 6 years after Orthotopic Liver Transplantation (OLT) were 83.7%, 82%, 82% and 82%, respectively. Mean and SE of Survival time of patients were 64.6 ± 1.7 (CI95%: 61.2-67.9). Short time and long time survival of these patients in both sexes and between age groups were similar. Multivariable analysis demonstrated that these improvements only be explained by donors age between 20-40 years old.
Conclusion: In summary, Orthotopic Liver Transplantation has developed into a safe and successful treatment for end-stage liver disease with satisfactory long-terms results. Our experience with liver transplantation indicates comparable success rate to similar reports.
Key words: Liver transplantation, Post transplant mortality, Outcome study, Survival analysis.
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