Associate Professor, Department of Physiology AND Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Metabolic syndrome is a chronic low-grade inflammation condition which is associated with central obesity, dyslipidemia, insulin resistance and hypertension. Inflammation in metabolic syndrome is not only associated with elevated serum inflammatory markers, such as C-reactive protein (CRP), but also, is associated with low-grade inflammation in adipose tissue and releasing of adipokines. Higher secretion of adipokines such as adiponectin and leptin, activated macrophages, and signaling pathways such as nuclear factor kappa B (NFkβ) are reported in adipocytes. It seems that more knowledge regarding the role of inflammatory markers in adipose tissue may be useful in management of metabolic syndrome.
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