Affected Host Cells in Male Reproductive Tissue and Relevant Signaling Pathways Associated with SARS-Cov-2 Infection

Document Type : Review Article

Authors

1 MSc, Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

2 BSc, Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

3 MSc, Department of Medical Genetics, School of Medical Sciences, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

4 Professor of Infertility & IVF, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

5 Assistant Professor of Medical biotechnology, Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

6 Professor of Molecular Cytogenetic, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

7 Assistant Professor of Cellular & Molecular Biology, Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background: COVID-19, caused by the SARS-CoV-2 virus, has been associated with damage to multiple organ systems. One of the noteworthy aspects of the virus is its effect on male fertility and the reproductive system. We aimed to overview the involved molecular pathways to prospect the virus's effects on male reproductive tissue, spermatogenesis, and semen parameters.
Methods: PubMed and Scopus databases (papers published from 2020 to 2023) were searched for studies reporting the impact of COVID-19 on the related pathways associated with the male reproductive system at the level of cells, and 98 articles were reviewed.
Findings: The effects of COVID-19 may arise directly due to the virus's attacks on the male reproductive system or may be due to an undesirable overreaction of the immune response, such as cytokines storm or fewer. Renin-Angiotensin System and PI3K/AKT signaling pathway are also involved; counts and sperm motility were decreased, although approximately recovery was observed in survivals within months. Contrasting the drugs used for treating COVID-19 that had contradictory effects regarding vaccines, it seems there is no tangible adverse effect on male fertility.
Conclusion: The impact of SARS-CoV-2 on male fertility and the reproductive system is notable due to the presence of two major host factors, ACE2 and TMPRSS2, and involving the related pathways. It is possible that these organs could be involved, leading to effects on future generations. Understanding the process may provide a clue for managing the efficacies.

Highlights

Bahia Namavar Jahromi: Google Scholar, PubMed

Pegah Mousavi: Google Scholar, PubMed

Soudabeh Sabetian: Google Scholar, PubMed

Keywords

Main Subjects

References

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Journal of Isfahan Medical School
Volume 42, Issue 768
4th Week, July
July and August 2024
Pages 418-430

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  • Receive Date: 06 April 2024
  • Accept Date: 22 July 2024

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