The Effect of Swimming Training and Aloe Vera Extract on Lipid Profile of Male Diabetic Rats

Document Type : Original Article (s)

Authors

1 PhD Student of Exercise Physiology, Department of Professional Physical Education, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Assistant Professor ,Department of Professional Physical Education , Science and Research Branch ,Islamic Azad University, Tehran ,Iran

3 Associate Professor, Department of Professional Physical Education , Science and Research Branch ,Islamic Azad University, Tehran ,Iran

Abstract

Background: Type 1 Diabetes is an autoimmune disorder which makes disorder in body metabolic activities. As herbal medicines have fewer side effects than many chemical medicines for treatment of the disease, aim of present study was to review the effect of swimming training and Aloe vera extract on lipid profile of diabetic rats.Methods: In this experimental research, 28 male rates selected and divided into 4 equal groups of control, swimming training, Aloe vera extract and swimming training with Aloe vera extract. Swimming training progressively started in first week by 6 minutes and increase to 36 minutes in sixth week. Groups 3 and 4 received 300 mg/kg peritoneal Aloe vera extract daily.Findings: Swimming training, Aloe vera extract and their combination had significant effects on improvement of lipid profile of diabetic rats (P < 0.05). Swimming training with Aloe vera extract significantly had more effect on improvement of lipid profile of diabetic rats compared to Aloe vera extract alone (P < 0.05). In addition, swimming training with Aloe vera extract significantly had more effects on improvement of very-low-density lipoprotein (VLDL), total cholesterol (TC) and triglyceride (TG) of diabetic rats compared to swimming training alone (P < 0.05).Conclusion: Swimming training with Aloe vera extract has interactional effect in improvement of lipid profile of diabetic rats.

Keywords

References

  1. Zhang X, Chen C. A new insight of mechanisms, diagnosis and treatment of diabetic cardiomyopathy. Endocrine 2012; 41(3): 398-409.
  2. Hayashi T, Nozawa M, Sohmiya K, Toko H, Nakao M, Okabe M, et al. Efficacy of pancreatic transplantation on cardiovascular alterations in diabetic rats: an ultrastructural and immunohistochemical study. Transplant Proc 1998; 30(2): 335-8.
  3. Jones SC. Diabetes, the heart, and the kidney. Proceedings of the 61st Scientific Sessions of the American Diabetes Association; 2001 Jun 22-26; Philadelphia, Pennsylvania
  4. Jarvisalo MJ, Putto-Laurila A, Jartti L, Lehtimaki T, Solakivi T, Ronnemaa T, et al. Carotid artery intima-media thickness in children with type 1 diabetes. Diabetes 2002; 51(2): 493-8.
  5. Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food Sci Nutr 2013; 64(6): 682-6.
  6. Larijani B. Diabetes and exercise. Tehran, Iran: Institute of Endocrinology and Metabolism; 2010. p. 4-15. [In Persian].
  7. Langmead L, Makins RJ, Rampton DS. Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro. Aliment Pharmacol Ther 2004; 19(5): 521-7.
  8. Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 1999; 49(447): 823-8.
  9. Ajabnoor MA. Effect of aloes on blood glucose levels in normal and alloxan diabetic mice. J Ethnopharmacol 1990; 28(2): 215-20.
  10. Nath D, Sethi N, Singh RK, Jain AK. Commonly used Indian abortifacient plants with special reference to their teratologic effects in rats. J Ethnopharmacol 1992; 36(2): 147-54.
  11. Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S. Beneficial effects of aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin Exp Pharmacol Physiol 2006; 33(3): 232-7.
  12. Rahimi N, Marandi SM, Kargarfard M. The effect of eight weeks aquatic training on lipid profile of patients who suffer from type II diabetes. J Isfahan Med Sch 2011; 29(148): 988-96. [In Persian].
  13. Chang CL, Lin Y, Bartolome AP, Chen YC, Chiu SC, Yang WC. Herbal therapies for type 2 diabetes mellitus: chemistry, biology, and potential application of selected plants and compounds. Evid Based Complement Alternat Med 2013; 2013: 378657.
  14. Lunz W, Peluzio MC, Dias CM, Moreira AP, Natali AJ. Long-term aerobic swimming training by rats reduces the number of aberrant crypt foci in 1,2-dimethylhydrazine-induced colon cancer. Braz J Med Biol Res 2008; 41(11): 1000-4.
  15. Ayoubi A, Omidi A, Valizade R, Mousaei A. Effect of hydroalcoholic extract of Aloe vera and Teucrium on serum glucose and lipid profile in streptozotocin diabetic male rats. J Birjand Univ Med Sci 2013; 20(2): 144-52. [In Persian].
  16. Ashraf H, Heydari R, Nejati V, Ilkhanipoor M. Preventive effect of Berberis integerrima on the serum levels of glucose and lipids in streptozotocin (STZ)-induced diabetes in rats. J Fasa Univ Med Sci 2012; 2(3):148-5. [In Persian].
  17. Owu DU, Antai AB, Udofia KH, Obembe AO, Obasi KO, Eteng MU. Vitamin C improves basal metabolic rate and lipid profile in alloxan-induced diabetes mellitus in rats. J Biosci 2006; 31(5): 575-9.
  18. Grundy SM, Benjamin IJ, Burke GL, Chait A, Eckel RH, Howard BV, et al. Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation 1999; 100(10): 1134-46.
  19. Parente EB, Guazzelli I, Ribeiro MM, Silva AG, Halpern A, Villares SM. Obese children lipid profile: effects of hypocaloric diet and aerobic physical exercise. Arq Bras Endocrinol Metabol 2006; 50(3): 499-504. [In Portuguese].
  20. Chen KT, Yang RS. Effects of exercise on lipid metabolism and musculoskeletal fitness in female athletes. World J Gastroenterol 2004; 10(1): 122-6.
  21. Kraus WE, Houmard JA, Duscha BD, Knetzger KJ, Wharton MB, McCartney JS, et al. Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med 2002; 347(19): 1483-92.
  22. Koozehchian MS, Nazem F, Kreider RB, Roberts WJ, Best TM, Rong Y, et al. The role of exercise training on lipoprotein profiles in adolescent males. Lipids Health Dis 2014; 13: 95.
  23. Ainslie PN, Reilly T, Maclaren DP, Campbell IT. Changes in plasma lipids and lipoproteins following 10-days of prolonged walking: influence of age and relationship to physical activity level. Ergonomics 2005; 48(11-14): 1352-64.
  24. Misawa E, Tanaka M, Nomaguchi K, Yamada M, Toida T, Takase M, et al. Administration of phytosterols isolated from Aloe vera gel reduce visceral fat mass and improve hyperglycemia in Zucker diabetic fatty (ZDF) rats. Obes Res Clin Pract 2008; 2(4): I-II.
  25. Choudhary M, Kochhar A, Sangha J. Hypoglycemic and hypolipidemic effect of Aloe vera L. in non-insulin dependent diabetics. J Food Sci Technol 2014; 51(1): 90-6.
  26. Agarwal OP. Prevention of atheromatous heart disease. Angiology 1985; 36(8): 485-92.
  27. Devaraj S, Yimam M, Brownell LA, Jialal I, Singh S, Jia Q. Effects of Aloe vera supplementation in subjects with prediabetes/metabolic syndrome. Metab Syndr Relat Disord 2013; 11(1): 35-40.
  28. Kamal-Eldin A, Moazzami A. Plant sterols and stanols as cholesterol-lowering ingredients in functional foods. Recent Pat Food Nutr Agric 2009; 1(1): 1-14.
  29. Saremi A. Sporting exercises and diabetes mellitus type 2: A review on evidences. Journal of Cell and Tissue 2011; 2(3): 171-81. [In Persian].
  30. Paoli A, Pacelli QF, Moro T, Marcolin G, Neri M, Battaglia G, et al. Effects of high-intensity circuit training, low-intensity circuit training and endurance training on blood pressure and lipoproteins in middle-aged overweight men. Lipids Health Dis 2013; 12: 131.
  31. Banz WJ, Maher MA, Thompson WG, Bassett DR, Moore W, Ashraf M, et al. Effects of resistance versus aerobic training on coronary artery disease risk factors. Exp Biol Med (Maywood ) 2003; 228(4): 434-40.
  32. Esfarjani F, Rashidi F, Marandi SM. The effect of aerobic exercise on blood glucose, lipid profile and apo. J Ardabil Univ Med Sci 2013; 13(2): 132-41. [In Persian].
  33. Alinejad-Mofrad S, Foadoddini M, Saadatjoo SA, Shayesteh M. Improvement of glucose and lipid profile status with Aloe vera in pre-diabetic subjects: a randomized controlled-trial. J Diabetes Metab Disord 2015; 14: 22.
  34. Trovati M, Carta Q, Cavalot F, Vitali S, Banaudi C, Lucchina PG, et al. Influence of physical training on blood glucose control, glucose tolerance, insulin secretion, and insulin action in non-insulin-dependent diabetic patients. Diabetes Care 1984; 7(5): 416-20.
  35. Ranallo RF, Rhodes EC. Lipid metabolism during exercise. Sports Med 1998; 26(1): 29-42.
  36. Marwick TH, Hordern MD, Miller T, Chyun DA, Bertoni AG, Blumenthal RS, et al. Exercise training for type 2 diabetes mellitus: impact on cardiovascular risk: a scientific statement from the American Heart Association. Circulation 2009; 119(25): 3244-62.
  37. Balducci S, Leonetti F, Di Mario U, Fallucca F. Is a long-term aerobic plus resistance training program feasible for and effective on metabolic profiles in type 2 diabetic patients? Diabetes Care 2004; 27(3): 841-2.
  38. Dunstan DW, Daly RM, Owen N, Jolley D, De Court M, Shaw J, et al. High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes Care 2002; 25(10): 1729-36.
  39. Sigal RJ, Kenny GP, Boule NG, Wells GA, Prud'homme D, Fortier M, et al. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med 2007; 147(6): 357-69.
  40. Castaneda C, Layne JE, Munoz-Orians L, Gordon PL, Walsmith J, Foldvari M, et al. A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care 2002; 25(12): 2335-41.
  41. Kelley DE, Goodpaster BH. Effects of exercise on glucose homeostasis in Type 2 diabetes mellitus. Med Sci Sports Exerc 2001; 33(6 Suppl): S495-S501.
Journal of Isfahan Medical School
Volume 34, Issue 411 - Serial Number 411
November and December 2017
Pages 1515-1522

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History

  • Receive Date: 19 September 2016
  • Revise Date:
  • Accept Date: 06 April 2022

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