Antifungal activity of Boswellia serrata's essential oil against fluconazole resistant and susceptible isolates of Candida albicans .

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Abstract

Candidiasis as an opportunistic infection is created by some species of Candida here the role of
Candida albicans is more noticeable than other species. Candida can make an extended variety
disease symptoms appear in human body. According to the increasing consumption of
immunosupress drugs including Corticostroides and some diseases like diabetes, this disease has
drown attention more than before. Considering the side effects of antifungal chemical drugs and
the high price of them.
We used the essential oil of Boswellia serrata against the isolates of Candida that are sensitive
and resistant to fluconazole, the number of samples that was used in this research was fifty.
Twenty five of them were sensitive to the fluconazole and the twenty five ones were resistant to
the fluconazole. So, in order to this experiment different (densities) were prepared in microplate.
Then one thousand of Candida albicans were added to each well and after twenty four hours of
incubation the number of Candida in each well was counted.
In group of sensitive isolates, three isolates didn’t grow up to the dilution of 1/32nd of essential
oil, seven isolates up to the dilution of 1/64 th , seven isolates up to the dilution of 1/128 th , eight
isolates up to the dilution of 1/256 th .
And in group of resistant isolates one isolate didn’t grow up to the dilution 1/32nd of essential oil,
six isolates up to the dilution of 1/64th , eight isolates up to the dilution of 1/128th and ten isolates
up to the dilution of 1/256th .

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Journal of Isfahan Medical School
Volume 24, Issue 82
October 2007
Pages 30-36

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  • Receive Date: 05 April 2022
  • Accept Date: 05 April 2022

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