Effect of Supplementary Vitamin D on Improvement of Glycemic Parameters in Patients with Type 2 Diabetic

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Internal Medicine, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran

2 Resident, Department of Internal Medicine and Endocrinology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran

3 Associate Professor, Department of of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Type 2 diabetes mellitus (T2DM) and Vitamin D deficiency, are too common disorders in the world. Various investigations argues the association between two diseases, however, findings are contradictory and controversial. The aim of the present study was to examine the effect of complementary vitamin D supplementation on improvement of various glycemic parameters in T2DM.Methods: In a double blind randomized clinical trial, 60 persons of T2DM patients were selected and divided into 2 groups with 30 patients. Group 1 were treated with oral Vitamin D (50,000 unit /week for 12 week), and group 2 were treated with placebo drug.Findings: The age of studied population were between 34 to 76 years and the mean age was 55 ± 10.7 years. Age, sex, BMI and serum levels of HbA1c and 25(OH) vitamin D were not significantly differ-ent between two groups before the study. After 12 weeks treatment intervention, no significant differ-ence was found in serum HbA1c and lipids between two groups.Conclusion: In this study weekly vitamin D supplementation for 12 weeks had not significant decre-mental effect on HbA1c and lipid profiles, however, further studies needs to evaluate clinical useful-ness of our findings.

Keywords

References

  1. John BB, Kenneth SP. Type 2 diabetes mellitus. In: Larsen PR, Kronenberg HM, Melmed Sh, Polonsky KS, editors. William's Textbook of Endocrinology. 11th ed. Philadelphia: Saunders, 2007. p. 1329-54.
  2. Takeda E, Yamamoto H, Taketani Y, Miyamoto K. Vitamin D-dependent rickets type I and type II. Acta Paediatr Jpn 1997; 39(4): 508-13.
  3. Bouillon R. Non-classical actions of the vitamin D. Bone 2007; 40(6): S9.
  4. Harris SS, Dawson-Hughes B. Seasonal changes in plasma 25-hydroxyvitamin D concentrations of young American black and white women. Am J Clin Nutr 1998; 67(6): 1232-6.
  5. Borissova AM, Tankova T, Kirilov G, Dakovska L, Kovacheva R. The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract 2003; 57(4): 258-61.
  6. Gedik O, Akalin S. Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man. Diabetologia 1986; 29(3): 142-5.
  7. Sesti G. Pathophysiology of insulin resistance. Best Pract Res Clin Endocrinol Metab 2006; 20(4): 665-79.
  8. Forouhi NG, Luan J, Cooper A, Boucher BJ, Wareham NJ. Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes 2008; 57(10): 2619-25.
  9. Chertow BS, Sivitz WI, Baranetsky NG, Cordle MB, DeLuca HF. Islet insulin release and net calcium retention in vitro in vitamin D-deficient rats. Diabetes 1986; 35(7): 771-5.
  10. Kumar S, Davies M, Zakaria Y, Mawer EB, Gordon C, Olukoga AO, et al. Improvement in glucose tolerance and beta-cell function in a patient with vitamin D deficiency during treatment with vitamin D. Postgrad Med J 1994; 70(824): 440-3.
  11. Tai K, Need AG, Horowitz M, Chapman IM. Glucose tolerance and vitamin D: effects of treating vitamin D deficiency. Nutrition 2008; 24(10): 950-6.
  12. Ortlepp JR, Lauscher J, Hoffmann R, Hanrath P, Joost HG. The vitamin D receptor gene variant is associated with the prevalence of type 2 diabetes mellitus and coronary artery disease. Diabet Med 2001; 18(10): 842-5.
  13. Iyengar S, Hamman RF, Marshall JA, Majumder PP, Ferrell RE. On the role of vitamin D binding globulin in glucose homeostasis: results from the San Luis Valley Diabetes Study. Genet Epidemiol 1989; 6(6): 691-8.
  14. Walter M, Kaupper T, Adler K, Foersch J, Bonifacio E, Ziegler AG. No effect of the 1alpha,25-dihydroxyvitamin D3 on beta-cell residual function and insulin requirement in adults with new-onset type 1 diabetes. Diabetes Care 2010; 33(7): 1443-8.
  15. Danescu LG, Levy S, Levy J. Vitamin D and diabetes mellitus. Endocrine 2009; 35(1): 11-7.
  16. Verges B. New insight into the pathophysiology of lipid abnormalities in type 2 diabetes. Diabetes Metab 2005; 31(5): 429-39.
  17. Rosen CJ. Clinical practice. Vitamin D insufficiency. N Engl J Med 2011; 364(3): 248-54.
  18. Bordelon P, Ghetu MV, Langan RC. Recognition and management of vitamin D deficiency. Am Fam Physician 2009; 80(8): 841-6.
  19. Hossein-Nezhad A, Maghbooli J, Arzaghi SM, Shafaei1 A, Rahmani1 M, Larijani B. Relationship between vitamin D Deficiency and gestational diabetes mellitus. Journal of Diabetes and Metabolic Disorders 2006; 5(3): 226-35.
  20. Giulietti A, Gysemans C, Stoffels K, van EE, Decallonne B, Overbergh L, et al. Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice. Diabetologia 2004; 47(3): 451-62.
  21. Champe PC, Harvey RA, Ferrier DR. Biochemitry. 4th ed. Philadelphia: Lippincott, Williams and Willkins; 2009. p. 510.
Journal of Isfahan Medical School
Volume 29, Issue 151 - Serial Number 151
July and August 2011
Pages 1157-1164

Files

History

  • Receive Date: 22 February 2011
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics