Efficacy and Side-Effects of Megestrol Acetate Tablets on Postpone Menstruation Compared with Low-Dose Estrogen Combined Oral Contraceptives (LD)

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Women's menstrual suppression is desired for many reasons. Menstrual suppresion, especially during the holidays, trips, camps, military exercises, special events, academic examinations or athletic events is desirable. This study, with emphasis on safety of megestrol acetate tablets, aimed to determine the effect of this tablet on retardation of menstruation compared with low-dose estrogen combined oral contraceptives (LD).Methods: In this clinical-trial study, 140 applicants to postpone menstruation left for pilgrimage randomly devided to two groups, LD and megestrol acetate recipients. Data were collected through a researcher-made questionnaire and were analyzed by Mann-Whitney Uand chi-square tests.Findings: The frequency of individuals reported symptoms such as headache or dizziness (P < 0.05), nausea or vomiting (P < 0.05), changes in appetite (P < 0.05) and changes in sexual desire (P < 0.05), was significantly more in the LD recipients compared with megestrol acetates.Conclusion: Megestrol acetate can be seen as a drug with the same efficacy of LD, but safer than it, to postpone the menstruation.

Keywords

References

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Journal of Isfahan Medical School
Volume 31, Issue 234 - Serial Number 234
March and April 2013
Pages 532-543

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History

  • Receive Date: 22 May 2013
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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