Comparison of Topical 5% Nicotinamid and 2% Clindamycin Gels in the Treatment of the Mild to Moderate Acne Vulgaris: A Double-Blinded Randomized Clinical Trial

Document Type : Original Article (s)

Authors

1 Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran AND Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Professor, Skin Diseases and Leishmaniasis Research Center AND Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Assistant Professor, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

4 Skin Diseases and Leishmaniasis Research center, Isfahan University of Medical Sciences, Isfahan, Iran

5 Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Background: Acne vulgaris is considered as one of the most common disorders for which, patients seek dermatologic care. In the current study, we evaluated the efficacy of the 5% nicotinamide gel versus 2% clindamycin gel in the treatment of the mild to moderate acne vulgaris.Methods: This randomized, controlled clinical trial was performed in 2009-2010. Sixty female patients with mild or moderate acne vulgaris were recruited to be treated either with 5% nicotinamide or 2% clindamycin gel for 8 weeks. Acne severity index (ASI) was used to evaluate the response to treatment and SPSS software was used to analyze the data.Findings: The mean of ASI at the baseline was 16.85 ± 8.50 and 18.20 ± 12.27 in nicotinamide and clindamycin groups, respectively (P > 0.0500). The mean of ASI was significantly decreased compared with baseline during the time in both groups (P < 0.0001). However, there was not any significant difference regarding reduction of ASI between the nicotinamide and clindamycin groups (P = 0.5830).Conclusion: Five percent nicotinamide gel is as effective as 2% clindamycin gel for treatment of mild to moderate acne vulgaris. No side effect was observed during the treatment. 

Keywords

References

  1. Kim RH, Armstrong AW. Current state of acne treatment: highlighting lasers, photodynamic therapy, and chemical peels. Dermatol Online J 2011; 17(3): 2.
  2. Niren NM. Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: a review. Cutis 2006; 77(1 Suppl): 11-6.
  3. Nilfroushzadeh MA, Siadat AH, Baradaran EH, Moradi S. Clindamycin lotion alone versus combination lotion of clindamycin phosphate plus tretinoin versus combination lotion of clindamycin phosphate plus salicylic acid in the topical treatment of mild to moderate acne vulgaris: a randomized control trial. Indian J Dermatol Venereol Leprol 2009; 75(3): 279-82.
  4. Iraji F, Sadeghinia A, Shahmoradi Z, Siadat AH, Jooya A. Efficacy of topical azelaic acid gel in the treatment of mild-moderate acne vulgaris. Indian J Dermatol Venereol Leprol 2007; 73(2): 94-6.
  5. Enshaieh S, Jooya A, Siadat AH, Iraji F. The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study. Indian J Dermatol Venereol Leprol 2007; 73(1): 22-5.
  6. Iraji F, Momeni A, Naji SM, Siadat AH. The efficacy of topical cyproterone acetate alcohol lotion versus placebo in the treatment of the mild to moderate acne vulgaris: a double blind study. Dermatol Online J 2006; 12(3): 26.
  7. Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol 2004; 3(2): 88-93.
  8. Barefoot SW. Nicotinic acid as an agent for counteracting iodide aggravation in acne vulgaris. AMA Arch Derm 1955; 71(4): 528-9.
  9. Marchand WE. The treatment of acne vulgaris with nicotinic acid induced vasodilatation. Mil Med 1955; 117(1): 60-2.
  10. Shalita AR, Smith JG, Parish LC, Sofman MS, Chalker DK. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. Int J Dermatol 1995; 34(6): 434-7.
  11. Sardesai VR, Kambli VM. Comparison of efficacy of topical clindamycin and nicotinamide combination with plain clindamycin for the treatment of acne vulgaris and acne resistant to topical antibiotics. Indian J Dermatol Venereol Leprol 2003; 69(2): 138-9.
  12. Draelos ZD, Matsubara A, Smiles K. The effect of 2% niacinamide on facial sebum production. J Cosmet Laser Ther 2006; 8(2): 96-101.
  13. Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A. Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. J Dermatolog Treat 2014; 25(2): 123-9.
  14. Titus S, Hodge J. Diagnosis and treatment of acne. Am Fam Physician 2012; 86(8): 734-40.
  15. Veraldi S, Giovene GL, Guerriero C, Bettoli V. Efficacy and tolerability of topical 0.2% Myrtacine (R) and 4% vitamin PP for prevention and treatment of retinoid dermatitis in patients with mild to moderate acne. G Ital Dermatol Venereol 2012; 147(5): 491-7.
Journal of Isfahan Medical School
Volume 32, Issue 316 - Serial Number 316
November and December 2015
Pages 2279-2285

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History

  • Receive Date: 03 July 2014
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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