Angiogenesis in Health and Disease: Role of Vascular Endothelial Growth Factor (VEGF)

Document Type : Review Article

Authors

1 MSc Student of Physiology, Student Research Committee, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

2 PhD Student in Reproductive Biology, Department of Anatomy, School of Medicine, Tehran University of Medical Sciences,Tehran,Iran.

3 Associate Professor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Background: Angiogenesis is the formation of new blood vessels from pre-existing ones. It contributes to physiological and pathophysiological conditions. Pathophysiological angiogenesis is associated with several long-term complications of disease such as diabetic retinopathy and nephropathy, endometriosis, hypertension and tumor development while physiological angiogenesis is involved in wound healing, ovulation and menstrual cycles. The process of angiogenesis depends on the balance of many stimulating or inhibiting factors. The key factor that regulates proliferation and migration of endothelial cells is the Vascular Endothelial Growth Factor (VEGF). Angiogenic therapy includes inhibition of abnormal angiogenesis in some conditions such as tumors or diabetes and stimulation of angiogenesis in conditions of ischemia, such as in ischemic heart disease or peripheral vascular disease. In this review, the mechanism of angiogenesis and role of VEGF during physiological and pathological conditions will be reviewed.Keywords:

Keywords

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Journal of Isfahan Medical School
Volume 29, Issue 132 - Serial Number 132
January and February 2011
Pages 312-326

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History

  • Receive Date: 01 May 2011
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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