Comparative Study of the Efficacy of CO2 and Fraxel Lasers in Treatment of Cutaneous Leishmaniasis Scars

Document Type : Original Article (s)

Authors

1 Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran AND Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Assistant Professor, Skin Diseases and Leishmaniasis Research Center, AND Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 General Practitioner, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: This study aimed to compare the efficacy of CO2 and Fraxel lasers on healing of the wound and the size of cutaneous leishmaniasis scars.Methods: In this randomized clinical trial study, 120 patients were randomly devided in two equal groups underwent CO2 and Fraxel lasers in treatment of leishmaniasis scars, respectively. In all cases, size and other aspects of scar were evaluated using a checklist before and 1, 3, and 6 months after the treatment.Findings: The patients' mean age was 27.21 ± 11.20 years. At the third and sixth months after the treatment, the healing rate of scars was statistically better in Fraxel laser group (49.2 and 76.8 percent, respectively) than CO2 laser group (36.7 and 44.7 percent, respectively) (P < 0.05 for both).Conclusions: Fraxel laser seems to be better than CO2 laser in variant aspects of treatment of leishmaniasis scars.

Keywords

References

  1. Berman JD. Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years. Clin Infect Dis 1997; 24(4): 684-703.
  2. World Health organization. Tropical Disease Research. 12th program report. UNDP/ world bank/ WHO special program for research and training disease (TDR). Geneva, Switzerland: WHO; 1995. p. 135-49.
  3. Ardehali S, Rezaei H. Leishmania and leishmaniasis. Tehran, Iran: Iran University Press; 1985. p. 149-60. [In Persian].
  4. Momeni A, Amin Javaheri M, Tajdidi M, Emamjomeh M. Theraputic and side effects of Glucantime in cutaneous leishmaniasis. Nabz 1993; 2: 5-10. [In Persian].
  5. Lerner EA, Grevelink SA. Leishmaniasis. In: Arndt KA, Robinson JK, Leboit PE, Wintroub BU, editors. Cutaneous medicine and surgery. 1st ed. Philadelphia, PA: Saunders; 1996. p. 1163-70.
  6. Vega Lopez F, Hay RJ. Parasitic worm and protozoa. In: Burns T, Breathnach S, Cox N, Griffiths CH. Rooks text book of dermatology. 7th ed. Maldenm, MA: Blackwell Science: 2004. p. 38-9, 42.
  7. Dowlati Y. Cutaneous leishmaniasis: clinical aspect. Clin Dermatol 1996; 14(5): 425-31.
  8. Nilforoushzade MA, Sadeghian G. Cutaneous leishmaniasis. Isfahan, Iran: Isfahan University of Medical Sciences; 2002. [In Persian].
  9. Thakur CP, Sinha GP, Pandey AK, Barat D, Singh RK. Daily versus alternate-day regimen of amphotericin B in the treatment of kala-azar: a randomized comparison. Bull World Health Organ 1994; 72(6): 931-6.
  10. Cassuto DA, Sadic NS, Scrimali L, Sirago P. An innovative device for fractional CO2 resurfacing: a preliminary clinical study. The American Journal of Cosmetic Surgery 2008; 25(2): 97-101.
  11. Tanzi EL, Wanitphakdeedecha R, Alster TS. Fraxel laser indications and long-term follow-up. Aesthet Surg J 2008; 28(6): 675-8.
  12. Alster TS, Tanzi EL, Lazarus M. The use of fractional laser photothermolysis for the treatment of atrophic scars. Dermatol Surg 2007; 33(3): 295-9.
  13. Chrastil B, Glaich AS, Goldberg LH, Friedman PM. Second-generation 1,550-nm fractional photothermolysis for the treatment of acne scars. Dermatol Surg 2008; 34(10): 1327-32.
  14. Nilforoushzadeh MA. Cutaneous leishmaniasis: treatment and prevention. Isfahan, Iran: Isfahan University of Medical Sciences; 1992. [In Persian].
  15. Rivera AE. Acne scarring: a review and current treatment modalities. J Am Acad Dermatol 2008; 59(4): 659-76.
  16. Nilforoushzadeh MA, Jafari F, Ansari N, Moradi Sh. The comparison between trichloroacetic acid 50% and CO2 laser in the treatment of cutaneous leishmaniasis scar. Iran J Dermatol 2007; 10(3): 181-6. [In Persian].
  17. Biotech Week Publication. Reliant technologies announces FDA clearance of the fraxel(R) Laser for the treatment of acne and surgical scars; physicians report fractional laser resurfacing achieves dramatic improvement [Online] 2006. Available from: URL: http://www.cosmeticsurgery-news.com/article2829.html/
  18. Lee HS, Lee JH, Ahn GY, Lee DH, Shin JW, Kim DH, et al. Fractional photothermolysis for the treatment of acne scars: a report of 27 Korean patients. J Dermatolog Treat 2008; 19(1): 45-9.
  19. AlGhammdi Kh. Treatment of atrophic leishmania scars by fractional laser. Proceedings of the Laser International 2010 Medical Applications Conference; 2010 Jan 11-13; Riadh, Saudi Arabia.
Journal of Isfahan Medical School
Volume 31, Issue 269 - Serial Number 269
November and December 2014
Pages 2277-2284

Files

History

  • Receive Date: 04 October 2012
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics