Serum OX40 Level in Patients with Neuromyelitis Optica

Document Type : Original Article (s)

Authors

1 MSc Student, Department of Immunology, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

2 Assistant Professor, Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Associate Professor, Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Professor, Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Neuromyelitis Optica (NMO) is an autoimmune inflammatory disease of the central nervous system (CNS), disturbing spinal cord and optic nerves specified by the presence of pathogenic serum autoantibodies against aquaporin 4 (AQP4) in the majority of patients . The role of T-cell is ambiguous. OX40 (CD134) is member of the tumor necrosis factor receptor family and is expressed selectively on activated T lymphocytes which increases in several autoimmune diseases. The aim of the study was to evaluate serum OX40 levels in patients with NMO.Methods: The study involved 19 patients with NMO and 19 controls. Serum OX40 levels were determined by the enzyme-linked immunosorbent assay (ELISA).Findings: The present study showed no significant different between OX40 levels in the serum of patients with NMO compared with controls (P = 0.378). Serum level of OX40 in women were lower than men (P = 0.470). In addition, we found that median serum OX40 levels in AQP4 Ab-serpositive were higher than seronegative NMO patient but was not statistically significant (P = 0.410).Conclusion: Serum OX40 levels could not be used as a diagnostic or treatment marker for NMO.

Keywords

References

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Journal of Isfahan Medical School
Volume 34, Issue 386 - Serial Number 386
May and June 2016
Pages 657-662

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History

  • Receive Date: 12 April 2016
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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