The Serum Level of Vitamin D and its Association with Disease Severity in Patients with Rheumatoid Arthritis

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Internal Medicine, Qom Branch, Islamic Azad University, Qom, Iran

2 Student of Medicine, Young Researchers and Elites Club, Qom Branch, Islamic Azad University, Qom, Iran

Abstract

Background: Rheumatoid arthritis is a chronic, progressive inflammatory disease that causes pain, stiffness, swelling and destruction of the articular tissues. This study aimed to evaluate the relationship between serum levels of vitamin D and disease severity in patients with rheumatoid arthritis.Methods: In this descriptive-analytic-sectional study was conducted in the city of Qom, Iran, 120 patients were enrolled based on the evaluation and consideration of inclusion and exclusion criteria using convenience sampling method. The activity or severity of disease was determined based on the disease activity score 28 (DAS28) criteria.Findings: 92 patients (76.7%) were women and the mean age of the patients was 48.26 ± 13.28 years. The serum vitamin D level was lower than normal in 19 patients (15.8%). The severity of the disease was reported as severe in 54 patients (45%), average in 51 patients (42.5%) and minor in 15 patients (12.5%). There was no significant relationship between the disease activity based on criteria and serum level of vitamin D (P > 0.05).Conclusion: According to the frequency and importance and effects of rheumatoid arthritis, more and more accurate and complete studies should be done in this area; then, the health departments can conclude details of preventive and curative approach in the context of the relationship between vitamin D and disease activity in patients with rheumatoid arthritis.

Keywords

References

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Journal of Isfahan Medical School
Volume 34, Issue 405 - Serial Number 405
September and October 2017
Pages 1311-1317

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History

  • Receive Date: 27 August 2016
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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