Investigation of Epidemiologic and Clinical Characteristics of Patients with Tongue Cancer in Two Tertiary Referral Centers in Isfahan City, Iran

Document Type : Original Article (s)

Authors

1 Professor, Department of Otorhinolaryngology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Oral cancers are one type of the common cancers in Iran. Tongue cancer as a great threat to public health is accounted for 30% of oral cancers. Therefore, current study aimed to analyze demographic and pathological characteristics of tongue cancer in a population of 260 patients diagnosed between 2004 and 2014 in Isfahan city, Iran.Methods: In this descriptive retrospective study, medical files of patients with tongue cancer who were referred to Alzahra and Kashani hospitals, as tertiary referral centers, from 2004 to 2014 were studied. Demographic characteristics (age, gender, and location), tumor features (location, type, and stage), and first manifestation at the time of diagnosis were extracted from medical files.Findings: The mean age of patients with tongue cancer was 66.48 ± 14.29 years and they were most frequently aged between 60 to 80 years (65.8%). Tongue cancer predominantly occurred in men (74.2%). Squamous cell carcinoma (SCC) was the most common type of tumor among patients with tongue cancer (71.9%).Conclusion: Tongue cancer predominantly occurs in men compared to women. Most of the patients with tongue cancer are aged more than 60 years and its occurrence in ages less than 40 years is rare. Further studies assessing risk factors and also effect of cultural, religious, and socioeconomic factors on occurrence of tongue cancer are suggested.

Keywords


  1. Moore SR, Johnson NW, Pierce AM, Wilson DF. The epidemiology of tongue cancer: a review of global incidence. Oral Dis 2000; 6(2): 75-84.
  2. Garcia-Kass AI, Herrero-Sanchez A, Esparza-Gomez G. Oral tongue cancer in public hospitals in Madrid, Spain (1990-2008). Med Oral Patol Oral Cir Bucal 2016; 21(6): e658-e664.
  3. Tsai MS, Lai CH, Lee CP, Yang YH, Chen PC, Kang CJ, et al. Mortality in tongue cancer patients treated by curative surgery: a retrospective cohort study from CGRD. PeerJ 2016; 4: e2794.
  4. Annertz K, Anderson H, Palmer K, Wennerberg J. The increase in incidence of cancer of the tongue in the Nordic countries continues into the twenty-first century. Acta Otolaryngol 2012; 132(5): 552-7.
  5. Razmpa E, Memari F, Naghibzadeh B. Epidemiologic and clinicopathologic characteristics of tongue cancer in Iranian patients. Acta Med Iran 2011; 49(1): 44-8.
  6. Sargeran K, Murtomaa H, Safavi SM, Vehkalahti M, Teronen O. Malignant oral tumors in iran: ten-year analysis on patient and tumor characteristics of 1042 patients in Tehran. J Craniofac Surg 2006; 17(6): 1230-3.
  7. Llewellyn CD, Johnson NW, Warnakulasuriya KA. Risk factors for squamous cell carcinoma of the oral cavity in young people--a comprehensive literature review. Oral Oncol 2001; 37(5): 401-18.
  8. Burzynski NJ, Flynn MB, Faller NM, Ragsdale TL. Squamous cell carcinoma of the upper aerodigestive tract in patients 40 years of age and younger. Oral Surg Oral Med Oral Pathol 1992; 74(3): 404-8.
  9. Li R, Koch WM, Fakhry C, Gourin CG. Distinct epidemiologic characteristics of oral tongue cancer patients. Otolaryngol Head Neck Surg 2013; 148(5): 792-6.