Interactive Effect of Aerobic Training and L-Carnitine Supplementation on Cardiac Tissue Apelin and Insulin Resistance in Diabetic Rats

Document Type : Original Article (s)

Authors

1 PhD Student, Department of Exercise Physiology, School of Physical Education, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran

2 Associate Professor, Department of Exercise Physiology, School of Physical Education, Razi University, Kermanshah, Iran

3 Assistant Professor, Department of Exercise Physiology, School of Physical Education, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran

4 Assistant Professor, Department of Corrective Exercise, School of Physical Education, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran

5 Assistant Professor, Department of Motor Behavior, School of Physical Education, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran

Abstract

Background: Adipokine apelin plays an important role in regulating energy homeostasis and improving insulin resistance. The purpose of this study was to investigate the interactive effect of aerobic exercise and L-carnitine supplementation on serum levels of cardiac tissue apelin and insulin resistance in diabetic rats.Methods: In this experimental study, 40 male rats were randomly divided into five groups of healthy control, diabetic control (placebo), diabetes + L-carnitine, diabetes + aerobic exercise, and diabetes + L-carnitine + exercise. After induction of diabetes in rats, aerobic exercise and L-carnitine supplementation were performed for six weeks and five sessions per week. Aerobic training in the active groups consisted of 10 minutes of treadmill exercise with 60% of maximal oxygen uptake, which increased by 20 minutes from the third week, with no control group training.Findings: There was a significant increase in apelin in the diabetes + aerobic training group and the diabetes + aerobic training + L-carnitine group compared to the control and placebo groups (P = 0.001). There was no significant difference between the two active groups (P = 0.227). There was a significant decrease in insulin and glucose levels in the active groups compared to the control and placebo groups, too (P = 0.001).Conclusion: Aerobic training and consumption of L-carnitine can increase cardiac tissue apelin and decrease insulin resistance.

Keywords

References

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Journal of Isfahan Medical School
Volume 37, Issue 549 - Serial Number 549
September and October 2020
Pages 1206-12012

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History

  • Receive Date: 12 October 2019
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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