The Levels of Serum Chromium and Manganese in Patients with Idiopathic Tinnitus Compared with Healthy Individuals

Document Type : Original Article (s)

Authors

1 Professor, Department of Otorhinolaryngology, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran

2 Resident, Department of Otorhinolaryngology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

3 Assistant Professor, Department of Otorhinolaryngology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Tinnitus is one of the most common and distressing otological problems. Oxidative processes are one of the mechanisms involved in tinnitus. Therefore, in the present study, the concentrations of antioxidant micronutrients (Cr and Mn) were determined in the serum of the patients with tinnitus in comparison with healthy subjects.Methods: In this case-control study, 55 patients with tinnitus and 47 healthy volunteers were enrolled, after matching age and sex. The concentrations of Cr and Mn were measured via flameless atomic absorption spectroscopy. Comparisons were made using Student’s t test.Findings: There was a significant decrease in mean Cr level of serum in patients with tinnitus comparing to the controls (P < 0.001). Moreover, there were no statistically significant differences between the mean serum levels of Mn in patients with tinnitus and controls (P = 0.770).Conclusion: In the present study, a relationship was seen between the serum level of trace element, Cr, and the occurrence of tinnitus. Trace elements are related to nutrition; so; investigation trace elements can be cost-effective and must be evaluated and considered in designing the treatment regimen for patients complaining of tinnitus. However, defining such a cause-and-effect relationship needs several prospective studies to be done.

Keywords

References

  1. Kalcioglu MT, Bayindir T, Erdem T, Ozturan O. Objective evaluation of the effects of intravenous lidocaine on tinnitus. Hear Res 2005; 199(1-2): 81-8.
  2. Yetiser S, Tosun F, Satar B, Arslanhan M, Akcam T, Ozkaptan Y. The role of zinc in management of tinnitus. Auris Nasus Larynx 2002; 29(4): 329-33.
  3. Heller AJ. Classification and epidemiology of tinnitus. Otolaryngol Clin North Am 2003; 36(2): 239-48.
  4. Baskill Jl. Relationships between tinnitus loudness and severity. Proceedings of the 6th International Tinnitus Seminar; 1999 Sep 5-9; Cambridge, UK. London, UK: The Tinnitus and Hyperactive Center; 1999. p. 424-28.
  5. Barnea G, Attias J, Gold S, Shahar A. Tinnitus with normal hearing sensitivity: extended high-frequency audiometry and auditory-nerve brain-stem-evoked responses. Audiology 1990; 29(1): 36-45.
  6. Neri S, Mauceri B, Cilio D, Bordonaro F, Messina A, Malaguarnera M, et al. Tinnitus and oxidative stress in a selected series of elderly patients. Arch Gerontol Geriatr Suppl 2002; 8: 219-23.
  7. Savastano M, Brescia G, Marioni G. Antioxidant therapy in idiopathic tinnitus: preliminary outcomes. Arch Med Res 2007; 38(4): 456-9.
  8. Hoekstra WG, Suttle JW, Ganther HE, Mertz W. Trace element metabolism in animals. Baltimore, MD: 1974. vol 2. p. 61
  9. Rubin W. Nutrition, biochemistry, and tinnitus. Int Tinnitus J 1999; 5(2): 144-5.
  10. Huang YL, Sheu JY, Lin TH. Association between oxidative stress and changes of trace elements in patients with breast cancer. Clin Biochem 1999; 32(2): 131-6.
  11. Jain SK, Lim G. Chromium chloride inhibits TNFalpha and IL-6 secretion in isolated human blood mononuclear cells exposed to high glucose. Horm Metab Res 2006; 38(1): 60-2.
  12. Hazane-Puch F, Benaraba R, Valenti K, Osman M, Laporte F, Favier A, et al. Chromium III histidinate exposure modulates gene expression in HaCaT human keratinocytes exposed to oxidative stress. Biol Trace Elem Res 2010; 137(1): 23-39.
  13. Le Prell CG, Dolan DF, Bennett DC, Boxer PA. Nutrient plasma levels achieved during treatment that reduces noise-induced hearing loss. Transl Res 2011; 158(1): 54-70.
  14. Henderson D, Bielefeld EC, Harris KC, Hu BH. The role of oxidative stress in noise-induced hearing loss. Ear Hear 2006; 27(1): 1-19.
  15. Yin H, Xu L, Porter NA. Free radical lipid peroxidation: mechanisms and analysis. Chem Rev 2011; 111(10): 5944-72.
  16. Grider A. Zinc, copper, and manganese. In: Stipanuk MH, Caudill MA, editors. Biochemical, physiological, and molecular aspects of human nutrition. Philadephia, PA: Elsevier Saunders; p. 828–48.
  17. Zelko IN, Mariani TJ, Folz RJ. Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic Biol Med 2002; 33(3): 337-49.
  18. Chang NC, Ho CK, Wu MT, Yu ML, Ho KY. Effect of manganese-superoxide dismutase genetic polymorphisms IVS3-23T/G on noise susceptibility in Taiwan. Am J Otolaryngol 2009; 30(6): 396-400.
  19. Asher BF, Seidman M, Snyderman C. Complementary and alternative medicine in otolaryngology. Laryngoscope 2001; 111(8): 1383-9.
  20. Danbolt NC. Glutamate uptake. Prog Neurobiol 2001; 65(1): 1-105.
Journal of Isfahan Medical School
Volume 33, Issue 340 - Serial Number 340
May and June 2015
Pages 992-998

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History

  • Receive Date: 26 April 2015
  • Revise Date:
  • Accept Date: 06 April 2022

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