Evaluation of the Association between Interleukin-6 Gene Polymorphism (IL6 174 G>C) with the Complications after the Coronary Artery Bypass Graft Surgery in Iranian Patients

Document Type : Original Article (s)

Authors

1 PharmD Candidate, Student Research Committee, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associate professor, Department of Clinical Pharmacy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

3 Assistant Professor, Department of Cardiothoracic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Associate Professor, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

5 Associate Professor, Department of Biostatistics and Epidemiology, School of Medicine, Najaf Abad Branch, Islamic Azad University, Isfahan, Iran

6 Associate Professor, Department of Medicinal Biotechnology, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Interleukin-6 (IL6) gene polymorphism is an important inflammatory cytokine. It may play a major role in complications observed after CABG surgery. Therefore, the present study was designed to study the relationship between IL6 174G>C gene polymorphism and complications after CABG. The aim of this study was to investigate any probable relationship between IL6 174 G >C polymorphism and complications observed after CABG surgery.Methods: In this case-control study, whole blood samples were obtained from all patients hospitalized for CABG surgery in Sina Hospital, Isfahan. Subject were divided into two groups of patients with (POC) or without (NPOC) complications. Information such as age, sex, degree of hemorrhage after the surgery, time spent in the intensive care unit (ICU), ventilation time, and inotropic support after the surgery was collected. Statistical analysis of the obtained data was performed using t-test and chi-square test.Findings: We did not find a correlation between IL6 gene polymorphism and complications after CABG surgery (P = 0.126). However, a significant difference was observed. This difference for GG was P = 0.05 and for GC was P = 0.035 between two groups.Conclusion: GG genotype may play a role for the inflammation and complications after CABG. Further studies with larger number of patients are recommended.

Keywords

References

  1. Libby P, Braunwald E, Bonow RO, Zipes DP. Braunwald's heart disease: a textbook of cardiovascular medicine. 8th ed. Philadelphia: Saunders/Elsevier; 2008.
  2. Banerjee I, Pandey U, Hasan OM, Parihar R, Tripathi V, Ganesh S. Association between inflammatory gene polymorphisms and coronary artery disease in an Indian population. J Thromb Thrombolysis 2009; 27(1): 88-94.
  3. Sanders J, Hawe E, Brull DJ, Hubbart C, Lowe GD, Rumley A, et al. Higher IL-6 levels but not IL6 -174G>C or -572G>C genotype are associated with post-operative complication following coronary artery bypass graft (CABG) surgery. Atherosclerosis 2009; 204(1): 196-201.
  4. Ueno M, Higashi A, Sakatai R. Rare bleeding complication of the radial artery conduit after coronary artery bypass grafting with endoscopic harvesting. Ann Thorac Cardiovasc Surg 2011; 17(2): 201-3.
  5. Faritous ZS, Aghdaie N, Yazdanian F, Azarfarin R, Dabbagh A. Perioperative risk factors for prolonged mechanical ventilation and tracheostomy in women undergoing coronary artery bypass graft with cardiopulmonary bypass. Saudi journal of anaesthesia 2011; 5(2): 167-9.
  6. Tomaszuk-Kazberuk A, Lewczuk A, Sobkowicz B, Goscicka K, Kozuch M, Dobrzycki S, et al. Is contrast echocardiography safe and useful for the assessment of left ventricular function in the perioperative period after cardiac surgery? A pilot study. Kardiol Pol 2011; 69(7): 680-6.
  7. Ezhov MV, Safarova MC, Afanas'eva OI, Il'ina LN, Liakishev AA, Pokrovskii SN. [High level of lipoprotein (a) as a predictor of poor long-term prognosis after coronary artery bypass surgery]. Kardiologiia 2011; 51(1): 18-22.
  8. Matsuo Y, Kuwabara M, Tanaka-Totoribe N, Kanai T, Nakamura E, Gamoh S, et al. The defective protein level of myosin light chain phosphatase (MLCP) in the isolated saphenous vein, as a vascular conduit in coronary artery bypass grafting (CABG), harvested from patients with diabetes mellitus (DM). Biochem Biophys Res Commun 2011; 412(2): 323-7.
  9. Podgoreanu MV, White WD, Morris RW, Mathew JP, Stafford-Smith M, Welsby IJ, et al. Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. Circulation 2006; 114(1 Suppl): I275-I281.
  10. Olivieri F, Antonicelli R, Cardelli M, Marchegiani F, Cavallone L, Mocchegiani E, et al. Genetic polymorphisms of inflammatory cytokines and myocardial infarction in the elderly. Mech Ageing Dev 2006; 127(6): 552-9.
  11. Male DK, Brostoff J, Roth DB, Roitt I. Immunology. 7th ed. Canada: Mosby Elsevier; 2006.
  12. Abbas AK, Lichtman AH. Basic Immunology: functions and disorders of the immune system. Philadelphia, Pa: Saunders; 2006.
  13. Ommen SR, Odell JA, Stanton MS. Atrial arrhythmias after cardiothoracic surgery. N Engl J Med 1997; 336(20): 1429-34.
  14. Fernandez-Real JM, Broch M, Vendrell J, Richart C, Ricart W. Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects. J Clin Endocrinol Metab 2000; 85(3): 1334-9.
  15. Moller SG, McPherson MJ. PCR. 2nd ed. Taylor & Francis; 2006.
  16. Maitra A, Shanker J, Dash D, John S, Sannappa PR, Rao VS, et al. Polymorphisms in the IL6 gene in Asian Indian families with premature coronary artery disease--the Indian Atherosclerosis Research Study. Thromb Haemost 2008; 99(5): 944-50.
  17. Sarecka-Hujar B, Zak I, Krauze J. Carrier-state of two or three polymorphic variants of MTHFR, IL-6 and ICAM1 genes increases the risk of coronary artery disease. Kardiol Pol 2008; 66(12): 1269-77.
  18. Georges JL, Loukaci V, Poirier O, Evans A, Luc G, Arveiler D, et al. Interleukin-6 gene polymorphisms and susceptibility to myocardial infarction: the ECTIM study. Etude Cas-Temoin de l'Infarctus du Myocarde. J Mol Med (Berl) 2001; 79(5-6): 300-5.
Journal of Isfahan Medical School
Volume 29, Issue 160 - Serial Number 160
September and October 2011
Pages 1750-1759

Files

History

  • Receive Date: 22 September 2011
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics