Evaluation and Comparison of Various Treatment Plannings for Ovarian Cancer Involving the Abdominal Area

Document Type : Original Article (s)

Authors

1 MSc Student, Department of Medical Physics and Engineering, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associate Professor, Department of Medical Physics and Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Radiation Oncologist, Department of Radiation-Oncology, Isfahan Milad Hospital, Isfahan, Iran

Abstract

Background: Radiation therapy is used to treat and control advanced ovarian cancer with spread to abdominal peritoneum. In this study, a comparison between various plans of radiation therapy within the abdomen and pelvis was performed in order to achieve an effective treatment response.Methods: Contouring and planning of 20 patients with CT-scan of the abdomen and pelvis were done by TiGRT software. In order to compare the different types of treatment planning for the selected site, some common criteria in radiotherapy and H-index were used.Findings: Among these methods, it was found that the two methods of anterior-posterior and lateral with 18 MV energy and same weight have same level of protection of organs at risk. While the tangent method do not produce a reasonable result. Moreover in anterior- posterior method can be shown that the changing in energy and beam weight give a various results from PTV covering and dose uniformity aspects.Conclusion: Among the various treatment planning were seen that AP/PA with AP = 6MV energy and weight 1, PA = 18 MV and weight 1.5, for covering whole abdomen give a better results.

Keywords

References

  1. de Angelis R, Sant M, Coleman MP, Francisci S, Baili P, Pierannunzio D, et al. Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE--5-a population-based study. Lancet Oncol 2014; 15(1): 23-34.
  2. Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res 2014; 74(11): 2913-21.
  3. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014; 64(1): 9-29.
  4. Aghajanian C, Blank SV, Goff BA, Judson PL, Teneriello MG, Husain A, et al. OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. J Clin Oncol 2012; 30(17): 2039-45.
  5. Buys SS, Partridge E, Black A, Johnson CC, Lamerato L, Isaacs C, et al. Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial. JAMA 2011; 305(22): 2295-303.
  6. Dembo AJ, Bush RS, Beale FA, Bean HA, Pringle JF, Sturgeon JF. The Princess Margaret Hospital study of ovarian cancer: stages I, II, and asymptomatic III presentations. Cancer Treat Rep 1979; 63(2): 249-54.
  7. Dembo AJ. Epithelial ovarian cancer: the role of radiotherapy. Int J Radiat Oncol Biol Phys 1992; 22(5): 835-45.
  8. Dinniwell R, Lock M, Pintilie M, Fyles A, Laframboise S, Depetrillo D, et al. Consolidative abdominopelvic radiotherapy after surgery and carboplatin/paclitaxel chemotherapy for epithelial ovarian cancer. Int J Radiat Oncol Biol Phys 2005; 62(1): 104-10.
  9. Langendijk JA, Connor NP. Late radiation-induced side effects. In: Harari PM, Connor NP, Grau C, Brady LW, Heilmannn HP, Mplls M, et al., editors. Functional preservation and quality of life in head and neck radiotherapy. New York, NY: Springer; 2009. p. 227-41.
  10. Cho JH, Chung WK, Kang W, Choi SM, Cho CK, Son CG. Manual acupuncture improved quality of life in cancer patients with radiation-induced xerostomia. J Altern Complement Med 2008; 14(5): 523-6.
  11. Jabbari K, Azarmahd N, Babazade S, Amouheidari A. Optimizing of the tangential technique and supraclavicular fields in 3 dimensional conformal radiation therapy for breast cancer. J Med Signals Sens 2013; 3(2): 107-16.
  12. Khan FM, Gibbons JP. Khan's The Physics of radiation therapy. 5th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2009.
  13. Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Bronnum D, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med 2013; 368(11): 987-98.
  14. Spratt DE, Pei X, Yamada J, Kollmeier MA, Cox B, Zelefsky MJ. Long-term survival and toxicity in patients treated with high-dose intensity modulated radiation therapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 2013; 85(3): 686-92.
  15. Jabbari K. Review of fast monte carlo codes for dose calculation in radiation therapy treatment planning. J Med Signals Sens 2011; 1(1): 73-86.
  16. Ling CC, Zhang P, Archambault Y, Bocanek J, Tang G, Losasso T. Commissioning and quality assurance of RapidArc radiotherapy delivery system. Int J Radiat Oncol Biol Phys 2008; 72(2): 575-81.
  17. Potter R, Haie-Meder C, van Limbergen E, Barillot I, De BM, Dimopoulos J, et al. Recommendations from gynaecological (GYN) GEC ESTRO working group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology. Radiother Oncol 2006; 78(1): 67-77.
  18. Kataria T, Sharma K, Subramani V, Karrthick KP, Bisht SS. Homogeneity Index: An objective tool for assessment of conformal radiation treatments. J Med Phys 2012; 37(4): 207-13.
  19. Helal A, Omar A. Homogeneity index: effective tool for evaluation of 3DCRT. Pan Arab Journal of Oncology 2015; 8(2):20-4.
  20. Yoon M, Park SY, Shin D, Lee SB, Pyo HR, Kim DY, et al. A new homogeneity index based on statistical analysis of the dose-volume histogram. J Appl Clin Med Phys 2007; 8(2): 9-17.
Journal of Isfahan Medical School
Volume 34, Issue 380 - Serial Number 380
March and April 2016
Pages 430-435

Files

History

  • Receive Date: 06 January 2016
  • Revise Date: 03 November 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics