Effect of Alive Protoscoleces of Hydatid Cyst on the Growth of Melanoma Cells in Mouse Model

Document Type : Original Article (s)

Authors

1 MSc Student, Department of Mycology and Parasitology, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

2 PhD Student, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3 PhD Student, Department of Mycology and Parasitology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Department of Mycology and Parasitology, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

5 Assistant Professor, Department of Mycology and Parasitology, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

6 Professor, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Hydatid cyst is the larval stage of Echinococcus granulosus. Effect of this parasite on inhibition of cancer cells growth has been shown in previous investigations.Methods: In this study, different numbers of viable protoscoleces of hydatid cyst were injected to C57/Black mice. Then, melanoma cells were injected to the mice, too.Findings: In mice received 100 or 500 protoscolices, significantly smaller tumors were developed in comparison with the control group; but in the group received 1000 protoscoleces, there was no significant difference in tumor size compared to control group.Conclusion: Probably, due to antigenic similarities between protoscolices and cancer cells, the raised antibody against protoscolices antigens may non-specifically affect tumor growth in mice.

Keywords

References

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Journal of Isfahan Medical School
Volume 32, Issue 281 - Serial Number 281
March and April 2014
Pages 486-492

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History

  • Receive Date: 16 November 2013
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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