Folic Acid Intake and Risk of Breast Cancer

Document Type : Review Article

Authors

1 PhD Candidate, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associate Professor, Department of Clinical Nutrition and Food Sciences, School of Nutrition Sciences, Isfahan University of Medical Sciences .Isfahan, Iran

Abstract

Background: Breast cancer is the most common invasive cancer in women, and also the most common cause of death from cancer and accounts for 25.2% of all newly diagnosed cancers in the world. Breast cancer is a multifactorial disease, and in addition to hereditary and environmental conditions, nutritional status and nutritional factors such as folate, vitamin B6 and B12, and alcohol may also be related to it.Methods: In this study, with the use of search engines PubMed, Proquest, Scopus, Science Direct, and Web of Science, and the keywords of breast cancer, breast neoplasms, folic acid and vitamin B9 were searched, on 13 case-control, 10 cohort, and 1 case series studies were found during the years 2007-2018.Findings: Studies have shown that a diet rich in folate is not associated with a reduced risk of breast cancer. The effect of folate on breast cancer is contradictory; folate consumption may lead to the prevention of breast cancer in the premenopausal age, and would mainly affect the negative receptor type. However, the difference in sample size, study area, study design, and evaluation methods may lead to heterogeneity in the results of the studies.Conclusion: The relationship between folate and breast cancer is ambiguous, and requires further studies to consider the state of menopause and hormone receptor in order to achieve clearer results in this regard.

Keywords

References

  1. Khalighfard S, Rajbi H, Gharakhanlou R, Khalighfard S, Setoudeh V, Alizadeh A. The Effect of 8 Weeks of Interval Aerobic Exercise before and after Induction of Breast Cancer on Serum Level of Irisin and Tumor Growth in Balb/c mice. J Isfahan Med Sch 2018; 35(459): 1775-84. [In Persian].
  2. Kennedy DA, Stern SJ, Moretti M, Matok I, Sarkar M, Nickel C, et al. Folate intake and the risk of colorectal cancer: a systematic review and meta-analysis. Cancer Epidemiol 2011; 35(1): 2-10.
  3. Chen P, Li C, Li X, Li J, Chu R, Wang H. Higher dietary folate intake reduces the breast cancer risk: a systematic review and meta-analysis. Br J Cancer 2014; 110(9): 2327-38.
  4. Kim HJ, Jung S, Eliassen AH, Chen WY, Willett WC, Cho E. Alcohol Consumption and Breast Cancer Risk in Younger Women According to Family History of Breast Cancer and Folate Intake. Am J Epidemiol 2017; 186(5): 524-31.
  5. Kolak A, Kaminska M, Sygit K, Budny A, Surdyka D, Kukielka-Budny B, et al. Primary and secondary prevention of breast cancer. Ann Agric Environ Med 2017; 24(4): 549-53.
  6. Hafezi G, Tavssoli M, Hemmati S, Safari F. The Association between CA Polymorphism in src Gene and Risk of Breast Cancer. J Isfahan Med Sch 2017; 35(419): 87-92. [In Persian].
  7. Vahid F, Hatami M, Sadeghi M, Ameri F, Faghfoori Z, Davoodi SH. The association between the Index of Nutritional Quality (INQ) and breast cancer and the evaluation of nutrient intake of breast cancer patients: A case-control study. Nutrition 2018; 45: 11-6.
  8. Najafi-Dorche S, Tavassoli M, Hemati S, Safari F. The Study of TAAAA Polymorphism in p53 Gene and Its Association with Breast Cancer. J Isfahan Med Sch 2015; 33(323): 134-43. [In Persian].
  9. Sharifi M, Moridnia A. Inducing Apoptosis and Decreases Cell Proliferation in Human Breast Cancer Cells through miR-182-5p Blockage Caused by Locked Nucleic Acid. J Isfahan Med Sch 2017; 35(418): 57-63. [In Persian].
  10. Hankinson SE, Colditz GA, Willett WC. Towards an integrated model for breast cancer etiology: the lifelong interplay of genes, lifestyle, and hormones. Breast Cancer Res 2004; 6(5): 213-8.
  11. Noroozi M, Rastegari Z, Paknahad Z. Type of body fat distribution in postmenopausal women and its related factors. Iran J Nurs Midwifery Res 2010; 15(1): 27-31.
  12. Haghighatdoost F, Paknahad Z. Soy Intake and Risk of Breast Cancer. J Health Syst Res 2013; 9(5): 449-59. [In Persian].
  13. Liu M, Cui LH, Ma AG, Li N, Piao JM. Lack of effects of dietary folate intake on risk of breast cancer: an updated meta-analysis of prospective studies. Asian Pac J Cancer Prev 2014; 15(5): 2323-8.
  14. Gong Z, Ambrosone CB, McCann SE, Zirpoli G, Chandran U, Hong CC, et al. Associations of dietary folate, Vitamins B6 and B12 and methionine intake with risk of breast cancer among African American and European American women. Int J Cancer 2014; 134(6): 1422-35.
  15. Yang D, Baumgartner RN, Slattery ML, Wang C, Giuliano AR, Murtaugh MA, et al. Dietary intake of folate, B-vitamins and methionine and breast cancer risk among Hispanic and non-Hispanic white women. PLoS One 2013; 8(2): e54495.
  16. Ericson U, Sonestedt E, Gullberg B, Olsson H, Wirfalt E. High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmo Diet and Cancer cohort. Am J Clin Nutr 2007; 86(2): 434-43.
  17. Maruti SS, Ulrich CM, White E. Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk. Am J Clin Nutr 2009; 89(2): 624-33.
  18. Tavani A, Malerba S, Pelucchi C, Dal ML, Zucchetto A, Serraino D, et al. Dietary folates and cancer risk in a network of case-control studies. Ann Oncol 2012; 23(10): 2737-42.
  19. Stevens VL, McCullough ML, Sun J, Gapstur SM. Folate and other one-carbon metabolism-related nutrients and risk of postmenopausal breast cancer in the Cancer Prevention Study II Nutrition Cohort. Am J Clin Nutr 2010; 91(6): 1708-15.
  20. Zhang YF, Shi WW, Gao HF, Zhou L, Hou AJ, Zhou YH. Folate intake and the risk of breast cancer: a dose-response meta-analysis of prospective studies. PLoS One 2014; 9(6): e100044.
  21. Shrubsole MJ, Shu XO, Li HL, Cai H, Yang G, Gao YT, et al. Dietary B vitamin and methionine intakes and breast cancer risk among Chinese women. Am J Epidemiol 2011; 173(10): 1171-82.
  22. Larsson SC, Bergkvist L, Wolk A. Folate intake and risk of breast cancer by estrogen and progesterone receptor status in a Swedish cohort. Cancer Epidemiol Biomarkers Prev 2008; 17(12): 3444-9.
  23. Weiwei Z, Liping C, Dequan L. Association between dietary intake of folate, vitamin B6, B12 & MTHFR, MTR Genotype and breast cancer risk. Pak J Med Sci 2014; 30(1): 106-10.
  24. de Batlle J, Ferrari P, Chajes V, Park JY, Slimani N, McKenzie F, et al. Dietary folate intake and breast cancer risk: European prospective investigation into cancer and nutrition. J Natl Cancer Inst 2015; 107(1): 367.
  25. Egnell M, Fassier P, Lecuyer L, Zelek L, Vasson MP, Hercberg S, et al. B-Vitamin Intake from Diet and Supplements and Breast Cancer Risk in Middle-Aged Women: Results from the Prospective NutriNet-Sante Cohort. Nutrients 2017; 9(5).
  26. Kim SJ, Zuchniak A, Sohn KJ, Lubinski J, Demsky R, Eisen A, et al. Plasma folate, vitamin B-6, and vitamin B-12 and breast cancer risk in B. Am J Clin Nutr 2016; 104(3): 671-7.
  27. Cancarini I, Krogh V, Agnoli C, Grioni S, Matullo G, Pala V, et al. Micronutrients Involved in One-Carbon Metabolism and Risk of Breast Cancer Subtypes. PLoS One 2015; 10(9): e0138318.
  28. Bassett JK, Baglietto L, Hodge AM, Severi G, Hopper JL, English DR, et al. Dietary intake of B vitamins and methionine and breast cancer risk. Cancer Causes Control 2013; 24(8): 1555-63.
  29. Jihene AB, Balti M, Estambouli N, Zribi A, Haddaoui A. 444 (PB-077) - Plasma homocysteine, folate, vitamin B12 and risk of breast cancer. Eur J Cancer 2018; 92: S129.
  30. Fereidani SS, Eini-Zinab H, Heidari Z, Jalali S, Sedaghat F, Rashidkhani B. Nutrient Patterns and Risk of Breast Cancer among Iranian Women: a Case- Control Study. Asian Pac J Cancer Prev 2018; 19(9): 2619-24.
  31. Matejcic M, de Batlle J, Ricci C, Biessy C, Perrier F, Huybrechts I, et al. Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort. Int J Cancer 2017; 140(6): 1246-59.
  32. Pirouzpanah S, Taleban FA, Mehdipour P, Atri M, Hooshyareh-rad A, Sabour S. The biomarker-based validity of a food frequency questionnaire to assess the intake status of folate, pyridoxine and cobalamin among Iranian primary breast cancer patients. Eur J Clin Nutr 2014; 68(3): 316-23.
  33. Zhang CX, Ho SC, Chen YM, Lin FY, Fu JH, Cheng SZ. Dietary folate, vitamin B6, vitamin B12 and methionine intake and the risk of breast cancer by oestrogen and progesterone receptor status. Br J Nutr 2011; 106(6): 936-43.
  34. Ericson U, Borgquist S, Ivarsson MI, Sonestedt E, Gullberg B, Carlson J, et al. Plasma folate concentrations are positively associated with risk of estrogen receptor beta negative breast cancer in a Swedish nested case control study. J Nutr 2010; 140(9): 1661-8.
  35. Gao CM, Tang JH, Cao HX, Ding JH, Wu JZ, Wang J, et al. MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese women. J Hum Genet 2009; 54(7): 414-8.
  36. Ma E, Iwasaki M, Kobayashi M, Kasuga Y, Yokoyama S, Onuma H, et al. Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan. Nutr Cancer 2009; 61(4): 447-56.
  37. Ma E, Iwasaki M, Junko I, Hamada GS, Nishimoto IN, Carvalho SM, et al. Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: A case-control study in Brazilian women. BMC Cancer 2009; 9: 122.
  38. Lin J, Lee IM, Cook NR, Selhub J, Manson JE, Buring JE, et al. Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women. Am J Clin Nutr 2008; 87(3): 734-43.
  39. Kabat GC, Miller AB, Jain M, Rohan TE. Dietary intake of selected B vitamins in relation to risk of major cancers in women. Br J Cancer 2008; 99(5): 816-21.
  40. Jung S, Wang M, Anderson K, Baglietto L, Bergkvist L, Bernstein L, et al. Alcohol consumption and breast cancer risk by estrogen receptor status: in a pooled analysis of 20 studies. Int J Epidemiol 2016; 45(3): 916-28.
  41. Larsson SC, Giovannucci E, Wolk A. Folate and risk of breast cancer: a meta-analysis. J Natl Cancer Inst 2007; 99(1): 64-76.
  42. Tio M, Andrici J, Eslick GD. Folate intake and the risk of breast cancer: A systematic review and meta-analysis. Breast Cancer Res Treat 2014; 145(2): 513-24.
Journal of Isfahan Medical School
Volume 36, Issue 500 - Serial Number 500
September and October 2017
Pages 1248-1260

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History

  • Receive Date: 08 July 2018
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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