The Effect of Aerobic Exercise Training on Epileptic Behaviors in the Kindled and Non-Kindled Rats with Pentylenetetrazole (PTZ)

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Physical Education and Sport Sciences, School of Human Sciences, University of Neyshabur, Neyshabur, Iran

2 Associate Professor, Department of Anatomical Sciences, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran

3 Assistant Professor, Department of Physiology and Pharmacology, Cellular and Molecular Research Center, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran

Abstract

Background: Exercise can be a supplementary therapy to treat seizures. However, there is little information on the extent of these effects in seizure-susceptible individuals. In this study, we investigated the simultaneous effects of aerobic exercise in the kindle and non-kindle rats with pentylenetetrazole (PTZ).Methods: In this experimental study, 40 rats were divided in 4 groups of kindled with PTZ injections that performed aerobic exercise for 6 weeks, sedentary kindled with PTZ injections, non-kindled that performed aerobic exercise for 6 weeks, and sedentary non-kindled. The non-kindled groups only received PTZ before and after 6-week period. 24 hours after the 6-week period, all groups received PTZ, and seizure parameters including stage 4 latency (S4L), stage 5 duration (S5D), and seizure duration (SD) were compared with before 6-week period. Repeated analysis of variance (ANOVA) and Bonferroni post hoc test were used for data analysis.Findings: In non-kindled animals, aerobic exercise reduced seizure parameters of S4L (P < 0.001) and SD (P < 0.050), and removed the generalized seizures. In kindled rats, it increased the latency time until the seizure onset (P< 0.001), and decreased the S5D and SD parameters (P < 0.001).Conclusion: The results showed that 6 weeks of aerobic activity reduced epileptic behaviors in kindled and non-kindled rats.

Keywords

References

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Journal of Isfahan Medical School
Volume 38, Issue 573 - Serial Number 573
March and April 2020
Pages 278-285

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History

  • Receive Date: 13 May 2020
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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