In-Vitro Effect of Hydro-Alcoholic Extract of Tanacetum Parthenium Extract on Trichomonas Vaginalis

Document Type : Original Article (s)

Authors

1 MSc Student, Department of Mycology and Parasitology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran

2 Department of Mycology and Parasitology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran

3 Student of Medicine, Students Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran

4 Professor, Department of Pharmacology AND Herbal Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

5 MSc Student, Department of Mycology and Parasitology, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

6 Professor, Infectious Diseases and Tropical Medicine Research Center AND Department of Mycology and Parasitology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Trichomonas vaginalisis a flagellate parasite causing vaginosis as a common sexual transmitted disease. Metronidazole is the drug of choice for this disease; but due to its side effects it is necessary to search for an alternative drug. In this study, the effect of Tanacetum parthenium on Trichomonas vaginalis was investigated.Methods: Using percolation method, hydro-alcoholic extracts of Tanacetum parthenium was prepared. The extract was dried using vacuum rotary evaporator. Different doses of the extract were added to 8 tubes containing culture medium of Trichomonas vaginalis; metronidazole was added to 1 tube. Finally, 104 Trichomonas vaginalis was added to each tube. Every 24 hours for 3 days, the tubes were seen for count and motion of the parasite under the microscope.Findings: In concentrations of 4, 5, 8 and 10 mg/ml of Tanacetum parthenium, the parasite did not grow. The effect of the extract on Trichomonas vaginalis was similar to the effect of metronidazole.Conclusion: Tanacetum parthenium has efficient effect against Trichomonas vaginalis growth in culture medium; so, this herb can be considered as alternative drug for methronidazole.

Keywords

References

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Journal of Isfahan Medical School
Volume 31, Issue 236 - Serial Number 236
March and April 2013
Pages 623-629

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History

  • Receive Date: 27 November 2012
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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