Nephrotoxicity of Hydroalcoholic Extract of Teucrium Polium in Wistar Rats

Document Type : Original Article (s)

Authors

1 Professor, Department of Nephrology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Professor, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

Abstract

Background: Teucrium polium L is widely used for different pathological conditions and may have side effects, especially on kidney. The aim of this study was to evaluate the nephrototoxicity of hydroalcoholic extract of Teucrium polium in male Wistar rats.Methods: In this experimental study, 100 rats were designated in 10 groups of 10. Five groups were injected intraperitoneally (IP) 50, 100, 150, or 200 mg /kg extracts or normal saline for 28 days and sacrificed to study the kidney degenerations. Five other groups were injected the same drug regimen, but they were sacrificed 28 days after cessation of drug injections to investigate the effect of possible complication or regeneration during recovery.Findings: The Teucrium polium consumption had dose-related toxic effects on kidney (P = 0.02). Following 28 days of Teucrium polium consumption (phase 1), kidney damages were not increased in comparison with control group (P > 0.05). However, following 28 days of drug cessation, kidney damages including degeneration, destruction and vacuolization were significantly appeared in comparison with control group and with increasing the doses of Teucrium polium (P = 0.03).Conclusion: Due to nephrotoxicity, Teucrium polium should not be used or should be consumed with great caution.

Keywords

References

  1. Rizk AM, Hammouda FM, Rimpler H, Kamel A. Iridoids and flavonoids of Teucrium polium herb. Planta Med 1986; (2): 87-8.
  2. Hajian S. Renoprotective effects of green tea. J Nephropharmacol 2013; 2(2):21-22.
  3. Nasri H. Impact of diabetes mellitus on parathyroid hormone in hemodialysis patients. J Parathyr Dis 2013; 1(1): 9-11.
  4. Rafieian-Kopaei M, Baradaran A. Teucrium polium and kidney. J Renal Inj Prev 2013; 2(1): 3-4.
  5. Vokou D, Bessiere JM. Volatile Constituents of Teucrium polium. J Nat Prod 1985; 48(3): 498-9.
  6. Autore G, Capasso F, De Fusco R, Fasulo MP, Lembo M, Mascolo N, et al. Antipyretic and antibacterial actions of Teucrium polium. Pharmacological Research Communications 1984; 16(1): 21-9.
  7. Tariq M, Ageel AM, al-Yahya MA, Mossa JS, al-Said MS. Anti-inflammatory activity of Teucrium polium. Int J Tissue React 1989; 11(4): 185-8.
  8. Kadifkova PT, Kulevanova S, Stefova M. In vitro antioxidant activity of some Teucrium species (Lamiaceae). Acta Pharm 2005; 55(2): 207-14.
  9. Rafieian-Kopaei M, Nasri H. Comment on: Preventive effect of Teucrium polium on learning and memory deficits in diabetic rats. Med Sci Monit Basic Res 2013; 19: 208-9.
  10. Alkofahi A, Atta AH. Pharmacological screening of the anti-ulcerogenic effects of some Jordanian medicinal plants in rats. J Ethnopharmacol 1999; 67(3): 341-5.
  11. Galati EM, Mondello MR, D'Aquino A, Miceli N, Sanogo R, Tzakou O, et al. Effects of Teucrium divaricatum Heldr. ssp. divaricatum decoction on experimental ulcer in rats. J Ethnopharmacol 2000; 72(1-2): 337-42.
  12. Abdollahi M, Karimpour H, Monsef-Esfehani HR. Antinociceptive effects of Teucrium polium L total extract and essential oil in mouse writhing test. Pharmacol Res 2003; 48(1): 31-5.
  13. Baluchnejadmojarad T, Roghani M, Roghani-Dehkordi F. Antinociceptive effect of Teucrium polium leaf extract in the diabetic rat formalin test. J Ethnopharmacol 2005; 97(2): 207-10.
  14. Nasri H, Behradmanesh S, Maghsoudi AR, Ahmadi A, Nasri P, Rafieian-Kopaei M. Efficacy of supplementary vitamin D on improvement of glycemic parameters in patients with type 2 diabetes mellitus; a randomized double blind clinical trial. J Renal Inj Prev 2014; 3(1): 31-4.
  15. Yazdanparas R, Esmaeili MA, Ashrafi Helan J. Teucrium polium extract effects pancreatic function of streptozotocin diabetic rats: A histopathological examination. Iran Biomed J 2005; 9(2): 81-5.
  16. Parsaee H, Shafiee-Nick R. Anti-spasmodic and anti-nociceptive effects of teucrium polium aqueous extract. Iran Biomed J 2006; 10(3): 145-9.
  17. Tamadon MR, Baradaran A, Rafieian-Kopaei M. Antioxidant and kidney protection; differential impacts of single and whole natural antioxidants. J Renal Inj Prev 2014; 3(2): 41-2.
  18. Sadraeisadraei H, Hajhashemi V, Ghannadi A, Mohseni M. Antispasmodic effect of aerial part of teucrium polium l. essential oil on rat isolated ileum in vitro. Med J I R Iran 2001; 14(4): 355-8.
  19. Rasekh HR, Khoshnood-Mansourkhani MJ, Kamalinejad M. Hypolipidemic effects of Teucrium polium in rats. Fitoterapia 2001; 72(8): 937-9.
  20. Shahraki MR, Arab MR, Mirimokaddam E, Palan MJ. The effect of teucrium polium (calpoureh) on liver function, serum lipids and glucose in diabetic male rats. Iran Biomed J 2007; 11(1): 65-8.
  21. Niazmand S, Erfanian Ahmadpoor M, Moosavian M, Derakhshan M. The positive inotropic and chronotropic effects of teucrium polium l. extract on guinea pig isolated heart. Pharmacologyonline 2008; 2: 588-94.
  22. Mardani S, Nasri P, Tavakoli M. Contrast induced nephropathy; recent findings. J Nephropharmacol 2013; 2(2): 27-30.
  23. Abu Sitta KH, Shomah MS, Salhab AS. Hepatotoxicity of 'Teucrium Polium' L Tea: Supporting Evidence in Mice Models [online]. Australian Journal of Medical Herbalism 2009; 21(4): 106-9.
  24. Jafarpoor N, Abbasi-Maleki S, Asadi-Samani M, Khayatnouri MH. Evaluation of antidepressant-like effect of hydroalcoholic extract of Passiflora incarnata in animal models of depression in male mice. J HerbMed Pharmacol 2014; 3(1):41- 45
  25. Rasekh HR, Khoshnood-Mansourkhani MJ, Kamalinejad M. Hypolipidemic effects of teucrium polium in rats. Fitoterapia 2001; 72(8): 937-9.
  26. Hajivandi A, Amiri M. World kidney day 2014: Kidney disease and elderly. J Parathyr Dis 2014; 2(1):3-4.
  27. Tavafi M. Inhibition of gentamicin-induced renal tubular cell necrosis. J Nephropathol 2012; 1(2): 83-6.
  28. Tavakoli M. Kidney protective effects of melatonin. J Nephropharmacol 2014; 3(1): 7-8.
  29. Baradaran A, Rafieian-kopaei M. Histopathological study of the combination of metformin and garlic juice for the attenuation of gentamicin renal toxicity in rats. J Renal Inj Prev 2013; 2(1): 15-21.
  30. Rafieian-Kopaie M, Nasri H. Silymarin and diabetic nephropathy. J Renal Inj Prev 2012; 1(1): 3-5.
  31. Mattei A, Rucay P, Samuel D, Feray C, Reynes M, Bismuth H. Liver transplantation for severe acute liver failure after herbal medicine (teucrium polium) administration. J Hepatol 1995; 22(5): 597.
  32. Larrey D, Vial T, Pauwels A, Castot A, Biour M, David M, et al. Hepatitis after germander (teucrium chamaedrys) administration: another instance of herbal medicine hepatotoxicity. Ann Intern Med 1992; 117(2): 129-32.
  33. Nasri H, Mubarak M. Contrast induced nephropathy has to be differentiated from kidney injury due to atheroembolic disease. J Renal Inj Prev 2012; 2(3): 107-8.
  34. Perez AJ, Saez-Royuela F, Gento PE, Lopez MA, Velasco OA, Martin LJ. [Acute hepatitis due to ingestion of Teucrium chamaedrys infusions]. Gastroenterol Hepatol 2001; 24(5): 240-3. [In Spanish]
  35. Nasri H. Cisplatin and renal injury; current concepts. J Renal Inj Prev 2013; 2(3): 89-90.
  36. Khleifat K, Shakhanbeh J, Tarawneh Kh. The chronic effects of teucrium polium on some blood parameters and histopathology of liver and kidney in the rat. Turkish Journal of Biolog 2002; 26(2): 65-71.
  37. Rafieian-Kopaie M. Medicinal plants for renal injury prevention. J Renal Inj Prev 2013; 2(2): 63-5.
  38. Nasri H, Shirzad H. Toxicity and safety of medicinal plants. J HerbMed Plarmacol. 2013; 2(2): 21-2.
  39. Ardalan MR, Sanadgol H, Nasri H, Baradaran A, Tamadon MR, Rafieian-Kopaei R. Impact of vitamin D on the immune system in kidney disease. J Parathyr Dis 2013; 1(2):17-20.
  40. Tamadon MR, Ardalan MR, Nasri H. World Kidney Day 2013; acute renal injury; a global health warning. J Parathyr Dis 2013;1(2):27-8.
  41. Namjoo AR, MirVakili M, Shirzad H, Faghani M. Biochemical, liver and renal toxicities of Melissa officinals hydroalcoholic extract on balb/C mice. J HerbMed Pharmacol. 2013; 2(2): 35-40.
  42. Kiani MA, Khodadad A, Mohammadi S, Ghayour Mobarhan M, Saeidi M, Jafari SA, et al. Effect of peppermint on pediatrics' pain under endoscopic examination of the large bowel. J HerbMed Pharmacol 2013; 2(2): 41-4.
  43. Kabiri N, Ahangar-Darabi M, Setorki M, Rafieian-kopaei M. The effect of silymarin on liver injury induced by Thioacetamide in rats. J HerbMed Pharmacol 2013; 2(2): 29-33.
  44. Tavafi M. Antioxidants against contrast media induced nephrotoxicity. J Renal Inj Prev 2014; 3(2):55-56.
  45. Nasri H, Ahmadi A, Baradaran A, Nasri P, Hajian S, Pour-Arian A, et al. A biochemical study on ameliorative effect of green tea (Camellia sinensis) extract against contrast media induced acute kidney injury. J Renal Inj Prev 2014; 3(1):47-49.
  46. Nasri H. The awareness of chronic kidney disease and aging; the focus of world kidney day in 2014. J Nephropharmacol.2014; 3(1):1-2.
  47. Asgari A. Herbal medicines and kidney; friends or foes? J Nephropharmacol 2014;3(1):5-6.
Journal of Isfahan Medical School
Volume 32, Issue 290 - Serial Number 290
May and June 2014
Pages 938-946

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History

  • Receive Date: 17 August 2013
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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